青紫霉素对大肠杆菌R因子抗性菌株的抗菌活性。
Antibacterial activity of lividomycin toward R factor-resistant strains of Escherichia coli.
作者信息
Yamaguchi M, Kobayashi F, Mitsuhashi S
出版信息
Antimicrob Agents Chemother. 1972 Feb;1(2):139-42. doi: 10.1128/AAC.1.2.139.
Abstract
Forty-eight R factors conferring resistance to both kanamycin (KM) and streptomycin (SM) were demonstrated from 1,270 Escherichia coli strains of clinical origin. Among these R factors isolated, 42 also conferred resistance to the new antibiotic lividomycin (LV). Extracts of E. coli ML1410 carrying one such factor (R(M81)) inactivated LV as well as KM and SM. But extracts of E. coli ML1410 carrying an R factor (R(M82) or R(M83)) sensitive to LV could not inactivate LV. LV inactivation required both adenosinetriphosphate (ATP) and Mg(2+). Inactivated LV was reactivable by alkaline phosphatase. Isotopic studies with labeled ATP and elemental analysis of the reaction product indicate that it is a monophosphorylated derivative of LV.
摘要
从1270株临床分离的大肠杆菌菌株中鉴定出48种对卡那霉素（KM）和链霉素（SM）均具有抗性的R因子。在这些分离出的R因子中，有42种还对新抗生素青紫霉素（LV）具有抗性。携带一种此类因子（R(M81)）的大肠杆菌ML1410提取物可使LV以及KM和SM失活。但携带对LV敏感的R因子（R(M82)或R(M83)）的大肠杆菌ML1410提取物不能使LV失活。LV失活需要三磷酸腺苷（ATP）和Mg(2+)。失活的LV可被碱性磷酸酶重新激活。用标记的ATP进行的同位素研究以及反应产物的元素分析表明，它是LV的单磷酸化衍生物。
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本文引用的文献
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