Dion H W, Woo P W, Willmer N E, Kern D L, Onaga J, Fusari S A
Antimicrob Agents Chemother. 1972 Aug;2(2):84-8. doi: 10.1128/AAC.2.2.84.
Butirosin, a new water-soluble aminoglycosidic antibiotic complex, active against gram-positive and gram-negative bacteria, has been isolated from fermentation filtrates of Bacillus circulans by ion exchange. The complex has been resolved into isomeric A and B components, C(21)H(41)N(5)O(12), by means of Dowex 1 x 1 or Dowex 1 x 2 chromatography. Properties of the free bases and the N, N', N'', N'''-tetraacetyl derivatives of butirosin A and B are given.
布替罗星是一种新型水溶性氨基糖苷类抗生素复合物，对革兰氏阳性菌和革兰氏阴性菌均有活性，它是通过离子交换从环状芽孢杆菌的发酵滤液中分离得到的。借助Dowex 1×1或Dowex 1×2色谱法，该复合物已被分解为异构体A和B组分，化学式为C(21)H(41)N(5)O(12)。文中给出了布替罗星A和B的游离碱以及N,N',N'',N'''-四乙酰基衍生物的性质。
