Greenwood D, Brooks H L, Gargan R, O'Grady F
J Clin Pathol. 1974 Mar;27(3):192-7. doi: 10.1136/jcp.27.3.192.
The effect of the new beta-lactam antibiotic FL 1060 on urinary tract pathogens, of which 71 were sensitive to and 100 resistant to ampicillin, is presented here. When tested by conventional methods FL 1060 was found to be highly active against ampicillin-sensitive strains of E. coli but phenotypically resistant variants readily emerged, particularly when a large inoculum was used. Thirty-one per cent of ampicillin-resistant strains were found to be sensitive to less than 500 mug FL 1060 per ml, and in general this antibiotic was more active than ampicillin against resistant strains. In a system simulating the mechanical features of the urinary bladder the activity of FL 1060 against three sensitive strains of E. coli was found to be greater than ampicillin in conditions of low, but not high, osmolality.
本文介绍了新型β-内酰胺抗生素FL 1060对尿路病原体的作用，其中71株对氨苄西林敏感，100株对氨苄西林耐药。采用传统方法检测时，发现FL 1060对氨苄西林敏感的大肠杆菌菌株具有高度活性，但表型耐药变异株很容易出现，尤其是在使用大量接种物时。发现31%的氨苄西林耐药菌株对每毫升低于500微克的FL 1060敏感，总体而言，这种抗生素对耐药菌株的活性比氨苄西林更强。在模拟膀胱机械特征的系统中，发现在低渗透压而非高渗透压条件下，FL 1060对三株敏感大肠杆菌菌株的活性大于氨苄西林。
