渗透压对大肠杆菌对美西林反应的影响。
Effect of osmolality on the response of Escherichia coli to mecillinam.
作者信息
Greenwood D
出版信息
Antimicrob Agents Chemother. 1976 Nov;10(5):824-6. doi: 10.1128/AAC.10.5.824.
Abstract
The influence of osmolality on the effect of the novel beta-lactam antibiotic, mecillinam, on Escherichia coli was examined in a turbidimetric system. Both sucrose and sodium chloride were able to protect E. coli from the effects of mecillinam during the stage of conversion to morphologically abnormal forms, and the additional presence of small amounts of magnesium sulfate protected the spherical forms from subsequent lysis. More phenotypically "resistant" survivors were recovered in osmotically protective media than in broth of low osmolality. Sucrose appeared a better protective agent than sodium chloride, but growth of the phenotypically resistant population was much slower in the sucrose-containing than in sodium chloride-containing medium.
摘要
在比浊法系统中研究了渗透压对新型β-内酰胺抗生素美西林对大肠杆菌作用效果的影响。在转化为形态异常形式的阶段，蔗糖和氯化钠均能保护大肠杆菌免受美西林的影响，并且少量硫酸镁的额外存在可保护球形形式免于随后的裂解。与低渗肉汤相比，在具有渗透压保护作用的培养基中可回收更多表型“抗性”的存活菌。蔗糖似乎是比氯化钠更好的保护剂，但含蔗糖培养基中表型抗性群体的生长比含氯化钠培养基中的慢得多。
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本文引用的文献
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