Simons M J, Wee G B, Chan S H, Shanmugaratnam K
Lancet. 1975 Jan 18;1(7899):142-3. doi: 10.1016/s0140-6736(75)91433-6.
An HL-A antigen profile comprising an increased frequency of HL-A2 and undetectable second-locus antigen(s) in Chinese patients with nasopharyngeal carcinoma (N.P.C.) has been reported. To investigate whether the deficit of second-locus antigen(s) had a genetic basis, sera from parous women in Singapore were screened for anti HL-A activity corresponding to the second-locus "bland". A second-locus (Singapore-2) was identified which seems to be associated with a high risk of N.P.C.
据报道，在中国鼻咽癌（NPC）患者中，HL-A抗原谱呈现出HL-A2频率增加且第二位点抗原不可检测的情况。为了研究第二位点抗原缺乏是否具有遗传基础，对新加坡有生育史的女性血清进行了筛查，以寻找与第二位点“空白”相对应的抗HL-A活性。已鉴定出一个第二位点（新加坡-2），它似乎与鼻咽癌的高风险相关。
