Simons M J, Wee G B, Goh E H, Chan S H, Shanmugaratnam K, Day N E, de-Thé G
J Natl Cancer Inst. 1976 Nov;57(5):977-80. doi: 10.1093/jnci/57.5.977.
The results of this study of 110 Singapore Chinese with nasopharyngeal carcinoma (NPC) and 91 controls confirmed the association between the occurrence of HLA antigen Singapore 2 (Sin2) and NPC in the Chinese population, and indicated that their increased risk for NPC was confined to the joint occurrence of Sin 2 and A2 antigens. These findings suggested that the genotype of importance in susceptibility to NPC is the A2-Sin 2 haplotype.
这项针对110名新加坡华裔鼻咽癌患者和91名对照者的研究结果证实，在中国人群中，HLA抗原新加坡2型（Sin2）的出现与鼻咽癌之间存在关联，并表明他们患鼻咽癌风险的增加仅限于Sin2和A2抗原的共同出现。这些发现表明，在鼻咽癌易感性方面重要的基因型是A2 - Sin2单倍型。
