Betuel H, Camoun M, Colombani J, Day N E, Ellouz R, de-Thé G
Int J Cancer. 1975 Aug 15;16(2):249-54. doi: 10.1002/ijc.2910160207.
Previous reports have demonstrated an association between the HL-A system and risk for nasopharyngeal carcinoma among the Chinese in Singapore. The present paper describes an investigation of HL-A profiles among NPC cases and non-NPC controls from Tunisia, to determine whether a similar association occurs in a different ethnic group. A total of 109 NPC cases and 84 controls were typed. At the second HL-A locus the results were similar to those found in Singapore, but the effect was less marked and did not reach high statistical significance. At the first HL-A locus, no association between A2 and NPC was found, in contrast to the Singapore results.
先前的报告已证明新加坡华人中HL-A系统与鼻咽癌风险之间存在关联。本文描述了对来自突尼斯的鼻咽癌病例和非鼻咽癌对照者的HL-A谱进行的一项调查，以确定在不同种族群体中是否会出现类似的关联。共对109例鼻咽癌病例和84名对照者进行了分型。在第二个HL-A位点，结果与在新加坡发现的结果相似，但影响较小且未达到高度统计学显著性。在第一个HL-A位点，与新加坡的结果相反，未发现A2与鼻咽癌之间存在关联。
