R 因子介导的基因对大肠杆菌某些表面特性的影响。
Effect of R-factor-mediated genes on some surface properties of Escherichia coli.
作者信息
Curtis N A, Richmond M H
出版信息
Antimicrob Agents Chemother. 1974 Dec;6(6):666-71. doi: 10.1128/AAC.6.6.666.
Abstract
The plasmid RP1 was shown to contain a genetic region (the irp region) responsible for influencing the intrinsic resistance of Escherichia coli to penicillins but not to cephalosporins. Mutants in which the irp genes are inactive were isolated. RP1 carrying functional irp genes protected E. coli AS19 against lysozyme lysis and also enhanced resistance to actinomycin D, to nalidixic acid, and to rifampin. This plasmid also phenotypically repaired the hypersensitivity to penicillins of strain AS19, and also that of E. coli envA mutants. Similar regions were not detected on the plasmids R1 and R55.
摘要
已证明质粒RP1含有一个遗传区域（irp区域），该区域负责影响大肠杆菌对青霉素的固有抗性，但不影响对头孢菌素的抗性。分离出了irp基因无活性的突变体。携带功能性irp基因的RP1保护大肠杆菌AS19免受溶菌酶裂解，还增强了对放线菌素D、萘啶酸和利福平的抗性。该质粒还在表型上修复了AS19菌株以及大肠杆菌envA突变体对青霉素的超敏感性。在质粒R1和R55上未检测到类似区域。
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