大肠杆菌K-12中R质粒R1、R1 bla-45和RP1所赋予的青霉素抗性与β-内酰胺酶活性之间的定量相关性。
Quantitative correlation between penicillin resistance and beta-lactamase activity specified by the R plasmids R1, R1 bla-45, and RP1 in Escherichia coli K-12.
作者信息
Crowlesmith I, Howe T G
出版信息
Antimicrob Agents Chemother. 1980 Nov;18(5):675-9. doi: 10.1128/AAC.18.5.675.
Abstract
A mutant of the R plasmid R1 which synthesizes a beta-lactamase with altered kinetic characteristics was isolated. The level of penicillin resistance specified by this plasmid was correctly predicted from the properties of the wild-type R1 according to a simple theoretical model published by Zimmermann and Rosselet (Antimicrob. Agents Chemother. 12:368--372, 1977). The model also accounts for the high level of penicillin resistance specified by the R plasmid RP1.
摘要
分离出了R质粒R1的一个突变体，它合成的β-内酰胺酶具有改变的动力学特性。根据齐默尔曼和罗斯莱特发表的一个简单理论模型（《抗菌剂与化疗》12:368 - 372, 1977），由该质粒确定的青霉素抗性水平可从野生型R1的特性中正确预测出来。该模型也解释了R质粒RP1所确定的高水平青霉素抗性。
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