豚鼠中带有尾足的淋巴细胞。胸腺起源的证据。
The uropod-bearing lymphocyte of the guinea pig. Evidence for thymic origin.
作者信息
Rosenstreich D L, Shevach E, Green I, Rosenthal A S
出版信息
J Exp Med. 1972 May 1;135(5):1037-48. doi: 10.1084/jem.135.5.1037.
Abstract
In this study, the frequency of uropod formation and the type of lymphocyte bearing the uropod was investigated in various guinea pig lymphocyte populations. Without prior in vitro stimulation, almost 40% of peritoneal exudate lymphocytes (PELS) form uropods, while thymocytes and lymph node cells form far fewer. Subsequent stimulation in vitro with purified protein derivative demonstrated that there is an association between antigen reactivity and frequency of uropod formation in these populations. The ultrastructure of these uropods is identical to that described for human lymphocytes stimulated with phytohemagglutinin. In the populations studied, all the lymphocytes forming uropods lack easily detectable surface membrane immunoglobulin and are therefore most likely thymus-derived or T lymphocytes.
摘要
在本研究中，我们调查了不同豚鼠淋巴细胞群体中尾足形成的频率以及带有尾足的淋巴细胞类型。未经事先体外刺激时，近40%的腹腔渗出淋巴细胞（PELS）会形成尾足，而胸腺细胞和淋巴结细胞形成的尾足则少得多。随后用纯化蛋白衍生物进行体外刺激表明，这些群体中抗原反应性与尾足形成频率之间存在关联。这些尾足的超微结构与用植物血凝素刺激的人类淋巴细胞所描述的相同。在所研究的群体中，所有形成尾足的淋巴细胞均缺乏易于检测到的表面膜免疫球蛋白，因此很可能是胸腺来源的或T淋巴细胞。
相似文献
1
The uropod-bearing lymphocyte of the guinea pig. Evidence for thymic origin.豚鼠中带有尾足的淋巴细胞。胸腺起源的证据。
J Exp Med. 1972 May 1;135(5):1037-48. doi: 10.1084/jem.135.5.1037.
2
The peritoneal exudate lymphocyte. I. Differences in antigen responsiveness between peritoneal exudate and lymph node lymphocytes from immunized guinea pigs.腹膜渗出淋巴细胞。I. 免疫豚鼠腹膜渗出淋巴细胞与淋巴结淋巴细胞抗原反应性的差异。
J Exp Med. 1971 Nov 1;134(5):1170-86. doi: 10.1084/jem.134.5.1170.
3
Cellular reactivity to tuberculin in immune and serologically-unresponsive guinea pigs.免疫和血清学无反应性豚鼠对结核菌素的细胞反应性。
J Immunol. 1970 Aug;105(2):527-30.
4
5
6
Development of cellular immunity in the human fetus: dichotomy of proliferative and cytotoxic responses of lymphoid cells to phytohemagglutinin.人类胎儿细胞免疫的发育：淋巴细胞对植物血凝素增殖反应和细胞毒性反应的二分法。
Proc Natl Acad Sci U S A. 1972 Jun;69(6):1440-4. doi: 10.1073/pnas.69.6.1440.
7
Thymus origin of lymphocytes reacting and stimulating reaction in mixed lymphocyte cultures--studies in the rat.混合淋巴细胞培养中发生反应并刺激反应的淋巴细胞的胸腺起源——大鼠研究
Clin Exp Immunol. 1972 Apr;10(4):649-59.
8
9
Heterogeneity of the cellular immune response. II. The role of adjuvant, lymphocyte stimulation in cutaneous basophil hypersensitivity.细胞免疫反应的异质性。II. 佐剂的作用，淋巴细胞刺激在皮肤嗜碱性粒细胞超敏反应中的作用。
J Exp Med. 1971 Feb 1;133(2):202-15. doi: 10.1084/jem.133.2.202.
10
Antigen-binding small lymphocytes in the guinea-pig. The immunological response to human thyroglobulin.豚鼠体内的抗原结合小淋巴细胞。对人甲状腺球蛋白的免疫反应。
Immunology. 1974 Jul;27(1):75-85.
引用本文的文献
1
A case of hand-mirror cell variant of multiple myeloma.
Int J Hematol. 2006 May;83(4):373-4. doi: 10.1532/IJH97.06037.
2
Scanning and transmission electron microscopy study of antibody-dependent lymphocyte-mediated cytotoxicity on measles virus-infected cells.抗体依赖性淋巴细胞介导的对麻疹病毒感染细胞的细胞毒性的扫描电镜和透射电镜研究
Infect Immun. 1980 Oct;30(1):303-15. doi: 10.1128/iai.30.1.303-315.1980.
3
Hypersensitivity pneumonitis in man. Light- and electron-microscopic studies of 18 lung biopsies.人类过敏性肺炎。18例肺活检的光镜和电镜研究。
Am J Pathol. 1983 Mar;110(3):275-89.
4
Evidence for cytotoxic T-lymphocyte-target cell interaction in brains of mice infected intracerebrally with lymphocytic choriomeningitis virus.淋巴细胞性脉络丛脑膜炎病毒脑内感染小鼠脑内细胞毒性T淋巴细胞与靶细胞相互作用的证据。
Acta Neuropathol. 1983;61(3-4):183-95. doi: 10.1007/BF00691984.
5
Ligand-induced movement of lymphocyte surface macromolecules. IV. Stimulation of cell motility by anti-Ig and lack of relationship to capping.配体诱导的淋巴细胞表面大分子运动。IV. 抗免疫球蛋白刺激细胞运动及其与帽化的无关性
J Exp Med. 1974 Feb 1;139(2):295-312. doi: 10.1084/jem.139.2.295.
6
Function of macrophages in antigen recognition by guinea pig T lymphocytes. I. Requirement for histocompatible macrophages and lymphocytes.豚鼠T淋巴细胞抗原识别中巨噬细胞的作用。I. 对组织相容性巨噬细胞和淋巴细胞的需求。
J Exp Med. 1973 Nov 1;138(5):1194-212. doi: 10.1084/jem.138.5.1194.
7
Regulation of lymphocyte responses in vitro: potentiation and inhibition of rat lymphocyte responses to antigen and mitogens by cytochalasin B.体外淋巴细胞反应的调节：细胞松弛素B对大鼠淋巴细胞对抗原和有丝分裂原反应的增强和抑制作用
Proc Natl Acad Sci U S A. 1972 Nov;69(11):3251-5. doi: 10.1073/pnas.69.11.3251.
8
Separation of thymus-derived and marrow-derived rat lymphocytes on glass bead columns.利用玻璃珠柱分离大鼠胸腺来源和骨髓来源的淋巴细胞。
Immunology. 1973 Apr;24(4):699-705.
9
Macrophage-lymphocyte clusters in the immune response to soluble protein antigen in vitro. II. Ultrastructure of clusters formed during the early response.体外对可溶性蛋白抗原免疫应答中的巨噬细胞-淋巴细胞簇。II. 早期应答期间形成的簇的超微结构。
J Exp Med. 1974 Nov 1;140(5):1260-72. doi: 10.1084/jem.140.5.1260.
10
Binding of aggregated gamma-globulin to activated T lymphocytes in the guinea pig.聚集的γ球蛋白与豚鼠活化T淋巴细胞的结合。
J Exp Med. 1974 Apr 1;139(4):1002-12. doi: 10.1084/jem.139.4.1002.
本文引用的文献
1
DEMONSTRATION OF MOUSE ISOANTIGENS AT THE CELLULAR LEVEL BY THE FLUORESCENT ANTIBODY TECHNIQUE.用荧光抗体技术在细胞水平上显示鼠同种抗原。
J Exp Med. 1961 Sep 30;114(4):415-34. doi: 10.1084/jem.114.4.415.
2
The immunological reactivity of the thymus.胸腺的免疫反应性。
Br J Exp Pathol. 1961 Aug;42(4):379-85.
3
Fractionation of splenic antibody-forming cells on glass bead columns.在玻璃珠柱上对脾抗体形成细胞进行分级分离。
J Immunol. 1967 Dec;99(6):1236-42.
4
5
Functional anatomy of the lymphocyte in immunological reactions in vitro.淋巴细胞在体外免疫反应中的功能解剖学
J Exp Med. 1966 Nov 1;124(5):851-8. doi: 10.1084/jem.124.5.851.
6
Microspikes on the lymphocyte uropod.淋巴细胞尾足上的微刺。
Science. 1969 Feb 21;163(3869):818-20. doi: 10.1126/science.163.3869.818.
7
Theta-bearing and complement-receptor lymphocytes are distinct populations of cells.携带θ抗原和补体受体的淋巴细胞是不同的细胞群体。
Science. 1971 Jul 9;173(3992):154-6. doi: 10.1126/science.173.3992.154.
8
The peritoneal exudate lymphocyte. I. Differences in antigen responsiveness between peritoneal exudate and lymph node lymphocytes from immunized guinea pigs.腹膜渗出淋巴细胞。I. 免疫豚鼠腹膜渗出淋巴细胞与淋巴结淋巴细胞抗原反应性的差异。
J Exp Med. 1971 Nov 1;134(5):1170-86. doi: 10.1084/jem.134.5.1170.
9
The mediator of cellular immunity. II. Migration of immunologically committed lymphocytes into inflammatory exudates.细胞免疫的介质。II. 免疫致敏淋巴细胞向炎性渗出物中的迁移。
J Exp Med. 1971 Feb 1;133(2):400-9. doi: 10.1084/jem.133.2.400.
10
The mediator of cellular immunity. I. The life-span and circulation dynamics of the immunologically committed lymphocyte.细胞免疫的介质。I. 免疫致敏淋巴细胞的寿命及循环动力学。
J Exp Med. 1971 Feb 1;133(2):389-99. doi: 10.1084/jem.133.2.389.
Zotero 插件