Chattopadhyay B
J Clin Pathol. 1972 Jun;25(6):531-3. doi: 10.1136/jcp.25.6.531.
In-vitro sensitivities were performed on 140 specimens of urine which grew Streptococcus faecalis of more than 100 000 organisms/ml between March 1970 and February 1971. Although the combination of trimethoprim and sulphamethoxazole definitely appeared to be more effective than sulphonamide alone and as effective as ampicillin, its use for more than two weeks in 14 cases of uncomplicated urinary tract infection due to Streptococcus faecalis led to development of resistance. As in these cases organisms were resistant to sulphonamide to start with, it is suggested that the combination should be used in prolonged treatment only where the organisms are sensitive to both the individual antibiotics. Ampicillin is still the drug of choice in urinary tract infection due to Streptococcus faecalis. The alternative appears to be rotational therapy with other potent antibiotics.
对1970年3月至1971年2月期间培养出每毫升超过100000个粪链球菌的140份尿液标本进行了体外敏感性试验。虽然甲氧苄啶和磺胺甲恶唑联合使用肯定比单独使用磺胺更有效，且与氨苄西林效果相当，但在14例由粪链球菌引起的非复杂性尿路感染中，使用该联合药物超过两周导致了耐药性的产生。由于在这些病例中，细菌一开始就对磺胺耐药，因此建议仅在细菌对两种单一抗生素均敏感的情况下，才将该联合药物用于长期治疗。氨苄西林仍是治疗粪链球菌引起的尿路感染的首选药物。替代方法似乎是使用其他强效抗生素进行轮换治疗。
