甲氧苄啶-磺胺甲恶唑与氨苄西林治疗慢性支气管炎急性加重期的单盲对照试验
Single-blind comparative trial of trimethoprim-sulphamethoxazole and ampicillin in the treatment of exacerbations of chronic bronchitis.
作者信息
Hughes D T
出版信息
Br Med J. 1969 Nov 22;4(5681):470-3. doi: 10.1136/bmj.4.5681.470.
Abstract
Fifty patients with exacerbations of chronic bronchitis were treated with either a combination of trimethoprim 320 mg. and sulphamethoxazole 1,600 mg. a day or ampicillin 2 g. a day. The trial, carried out as a single-blind procedure, showed that the combination was more effective as judged by clinical response and reduction in sputum volume and purulence, with eradication of pathogenic organisms. No appreciable side-effects were encountered with either treatment, and it is suggested that the trimethoprim-sulphamethoxazole combination may be a safe and useful drug in the treatment of chronic bronchitis.
摘要
50例慢性支气管炎急性发作患者分别接受以下治疗：每日服用甲氧苄啶320毫克与磺胺甲恶唑1600毫克的组合，或每日服用2克氨苄西林。该试验采用单盲程序进行，结果显示，从临床反应、痰液量减少以及痰液脓性减轻并根除致病微生物的角度判断，上述组合更为有效。两种治疗方法均未出现明显副作用，有人认为甲氧苄啶 - 磺胺甲恶唑组合可能是治疗慢性支气管炎的一种安全有效的药物。
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Single-blind comparative trial of trimethoprim-sulphamethoxazole and ampicillin in the treatment of exacerbations of chronic bronchitis.甲氧苄啶-磺胺甲恶唑与氨苄西林治疗慢性支气管炎急性加重期的单盲对照试验
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