甲氧苄啶-磺胺甲恶唑与氨苄西林治疗慢性支气管炎急性加重期的单盲对照试验
Single-blind comparative trial of trimethoprim-sulphamethoxazole and ampicillin in the treatment of exacerbations of chronic bronchitis.
作者信息
Hughes D T
出版信息
Br Med J. 1969 Nov 22;4(5681):470-3. doi: 10.1136/bmj.4.5681.470.
Abstract
Fifty patients with exacerbations of chronic bronchitis were treated with either a combination of trimethoprim 320 mg. and sulphamethoxazole 1,600 mg. a day or ampicillin 2 g. a day. The trial, carried out as a single-blind procedure, showed that the combination was more effective as judged by clinical response and reduction in sputum volume and purulence, with eradication of pathogenic organisms. No appreciable side-effects were encountered with either treatment, and it is suggested that the trimethoprim-sulphamethoxazole combination may be a safe and useful drug in the treatment of chronic bronchitis.
摘要
50例慢性支气管炎急性发作患者分别接受以下治疗：每日服用甲氧苄啶320毫克与磺胺甲恶唑1600毫克的组合，或每日服用2克氨苄西林。该试验采用单盲程序进行，结果显示，从临床反应、痰液量减少以及痰液脓性减轻并根除致病微生物的角度判断，上述组合更为有效。两种治疗方法均未出现明显副作用，有人认为甲氧苄啶 - 磺胺甲恶唑组合可能是治疗慢性支气管炎的一种安全有效的药物。
相似文献
1
Single-blind comparative trial of trimethoprim-sulphamethoxazole and ampicillin in the treatment of exacerbations of chronic bronchitis.甲氧苄啶-磺胺甲恶唑与氨苄西林治疗慢性支气管炎急性加重期的单盲对照试验
Br Med J. 1969 Nov 22;4(5681):470-3. doi: 10.1136/bmj.4.5681.470.
2
A comparison of trimethoprim-sulphamethoxazole compound and tetracycline in exacerbations of chronic bronchitis. A double-blind multi-centre trial on in-patients.
Br J Dis Chest. 1972 Jul;66(3):199-206. doi: 10.1016/0007-0971(72)90031-9.
3
4
[Clinical and bacteriological study of the effects of trimethoprim-sulfamethoxazole in chronic bronchitis].[甲氧苄啶-磺胺甲恶唑对慢性支气管炎影响的临床及细菌学研究]
Prax Pneumol. 1970 May;24(5):300-7.
5
Tetracycline and co-trimoxazole in acute exacerbations of chronic bronchitis.四环素与复方新诺明用于慢性支气管炎急性加重期
Br J Dis Chest. 1973 Jul;67(3):241-5. doi: 10.1016/0007-0971(73)90060-0.
6
Trimethoprim-sulfamethoxazole compared with ampicillin in acute infectious exacerbations of chronic bronchitis: a double-blind, crossover study.甲氧苄啶-磺胺甲恶唑与氨苄西林治疗慢性支气管炎急性感染性加重的比较：一项双盲交叉研究。
J Infect Dis. 1973 Nov;128:Suppl:710-8 p. doi: 10.1093/infdis/128.supplement_3.s710.
7
A double-blind cross-over trial of trimethoprim and sulphamethoxazole in chronic bronchitis.甲氧苄啶与磺胺甲恶唑治疗慢性支气管炎的双盲交叉试验。
Thorax. 1971 May;26(3):319-24. doi: 10.1136/thx.26.3.319.
8
Single-blind comparative trial of trimethoprim-sulphamethoxazole and ampiclox.
S Afr Med J. 1972 Mar 18;46(12):318-21.
9
Trimethoprim--sulphamethoxazole: comparative study in urinary infection in hospital.甲氧苄啶-磺胺甲恶唑：医院内尿路感染的对比研究
Br Med J. 1969 Mar 1;1(5643):541-4. doi: 10.1136/bmj.1.5643.541.
10
Trimethoprim-sulphamethoxazole in chronic bronchitis.
Practitioner. 1969 Dec;203(218):817-9.
引用本文的文献
1
MgrB Inactivation Confers Trimethoprim Resistance in .MgrB失活赋予[具体对象]对甲氧苄啶的抗性 。 （原文此处信息不完整）
Front Microbiol. 2021 Jul 28;12:682205. doi: 10.3389/fmicb.2021.682205. eCollection 2021.
2
Deletion of Causes Increased Susceptibility to Antifolates in Escherichia coli and Salmonella enterica.基因缺失导致大肠杆菌和肠炎沙门氏菌对叶酸拮抗剂的敏感性增加。
Antimicrob Agents Chemother. 2017 Apr 24;61(5). doi: 10.1128/AAC.02378-16. Print 2017 May.
3
Optimal antibiotic therapy in bronchopulmonary infections.支气管肺部感染的最佳抗生素治疗
Infection. 1980;Suppl 1:62-9. doi: 10.1007/BF01644938.
4
Sulphamethoxazole-trimethoprim: the first two years.磺胺甲恶唑-甲氧苄啶：头两年
J Clin Pathol. 1971 Jul;24(5):430-7. doi: 10.1136/jcp.24.5.430.
5
Effect of trimethoprim-sulphamethoxazole combination on folate metabolism in malnourished children.甲氧苄啶-磺胺甲恶唑联合用药对营养不良儿童叶酸代谢的影响。
Arch Dis Child. 1972 Aug;47(254):626-30. doi: 10.1136/adc.47.254.626.
6
Toxicity of trimethoprim-sulphamethoxazole in patients with megaloblastic haemopoiesis.甲氧苄啶-磺胺甲恶唑对巨幼细胞造血患者的毒性
Br Med J. 1972 Mar 11;1(5801):651-3. doi: 10.1136/bmj.1.5801.651.
7
Trimethoprim-sulphamethoxazole in enteric fevers.甲氧苄啶-磺胺甲恶唑用于伤寒热。
Br Med J. 1970 Aug 8;3(5718):323-4. doi: 10.1136/bmj.3.5718.323.
8
Editorial: Treatment of acute exacerbations of chronic bronchitis.
Br Med J. 1973 Nov 24;4(5890):437-8. doi: 10.1136/bmj.4.5890.437.
9
Trimethoprim-sulphamethoxazole in urinary tract infection due to Streptococcus faecalis.甲氧苄啶-磺胺甲恶唑用于粪肠球菌引起的尿路感染
J Clin Pathol. 1972 Jun;25(6):531-3. doi: 10.1136/jcp.25.6.531.
10
Trimethoprim-resistance and its transferability in E. coli isolated from calves treated with trimethoprim-sulphadiazine: a two year study.从用甲氧苄啶-磺胺嘧啶治疗的犊牛中分离出的大肠杆菌对甲氧苄啶的耐药性及其可转移性：一项为期两年的研究。
J Hyg (Lond). 1973 Dec;71(4):669-77. doi: 10.1017/s0022172400022932.
本文引用的文献
1
AMPICILLIN IN THE TREATMENT OF HAEMOPHILUS INFLUENZAE INFECTIONS OF THE RESPIRATORY TRACT.氨苄西林治疗呼吸道流感嗜血杆菌感染
Thorax. 1964 Jul;19(4):298-305. doi: 10.1136/thx.19.4.298.
2
INFLUENCE OF DAILY PENICILLIN, TETRACYCLINE, ERYTHROMYCIN, AND SULPHAMETHOXYPYRIDAZINE ON EXACERBATIONS OF BRONCHITIS. A REPORT TO THE RESEARCH COMMITTEE OF THE BRITISH TUBERCULOSIS ASSOCIATION.每日服用青霉素、四环素、红霉素和磺胺甲氧嗪对支气管炎发作的影响。提交给英国结核病协会研究委员会的一份报告。
Br Med J. 1964 Mar 21;1(5385):728-32. doi: 10.1136/bmj.1.5385.728.
3
5-BENZYL-2,4-DIAMINOPYRIMIDINES AS ANTIBACTERIAL AGENTS. I. SYNTHESIS AND ANTIBACTERIAL ACTIVITY IN VITRO.5-苄基-2,4-二氨基嘧啶类抗菌剂。I. 体外合成与抗菌活性
J Med Pharm Chem. 1962 Nov;5:1103-23. doi: 10.1021/jm01241a004.
4
A trial of continuous winter chemotherapy in chronic bronchitis.
Lancet. 1960 Oct 1;2(7153):723-7. doi: 10.1016/s0140-6736(60)91792-x.
5
Antagonists of nucleic acid derivatives. VIII. Synergism in combinations of biochemically related antimetabolites.核酸衍生物拮抗剂。VIII. 生物化学相关抗代谢物组合中的协同作用。
J Biol Chem. 1954 Jun;208(2):477-88.
6
Trimethoprim: laboratory and clinical studies.甲氧苄啶：实验室研究与临床研究
J Clin Pathol. 1968 Mar;21(2):202-9. doi: 10.1136/jcp.21.2.202.
7
Effects of trimethoprim on folate metabolism in man.
Clin Pharmacol Ther. 1968 Sep-Oct;9(5):550-60. doi: 10.1002/cpt196895550.
8
Trimethoprim in the treatment of urinary infections in hospital.甲氧苄啶用于医院内尿路感染的治疗
Br Med J. 1969 Mar 1;1(5643):545-7. doi: 10.1136/bmj.1.5643.545.
9
Trimethoprim and sulphamethoxazole in the treatment of chronic chest infections.
Chemotherapy. 1969;14(3):151-7. doi: 10.1159/000220624.
10
Trimethoprim--sulphamethoxazole: comparative study in urinary infection in hospital.甲氧苄啶-磺胺甲恶唑：医院内尿路感染的对比研究
Br Med J. 1969 Mar 1;1(5643):541-4. doi: 10.1136/bmj.1.5643.541.
Zotero 插件