B群脑膜炎奈瑟菌多糖的产生与降解
Production and degradation of serogroup B Neisseria meningitidis polysaccharide.
作者信息
Maloney P C, Schneider H, Brandt B L
出版信息
Infect Immun. 1972 Nov;6(5):657-8. doi: 10.1128/iai.6.5.657-661.1972.
Abstract
Polysaccharide produced from cultures of serogroups A, B, and C Neisseria meningitidis was assayed by the serogroup-specific hemagglutination inhibition (HAI) test. The polysaccharide produced by all serogroups was found to increase during the exponential phase of growth. For serogroups A and C, the HAI activity was stable during the stationary phase; for serogroup B, however, the HAI decayed rapidly. The degradation of the serogroup B polysaccharide was not caused by enzymatic degradation, but was due to acid accumulation in the culture medium. The large-molecular-size serogroup B polysaccharide was stabilized by increasing the buffering capacity of the medium, which also increased the yield of this antigen.
摘要
用血清群特异性血凝抑制（HAI）试验测定了A、B和C血清群脑膜炎奈瑟菌培养物产生的多糖。发现所有血清群产生的多糖在生长指数期增加。对于A和C血清群，HAI活性在稳定期保持稳定；然而，对于B血清群，HAI活性迅速衰减。B血清群多糖的降解不是由酶促降解引起的，而是由于培养基中酸的积累。通过增加培养基的缓冲能力使大分子大小的B血清群多糖稳定，这也提高了该抗原的产量。
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