关于果蝇基因组结构的一项提议。
A proposal for the structure of the Drosophila genome.
作者信息
Bonner J, Wu J R
出版信息
Proc Natl Acad Sci U S A. 1973 Feb;70(2):535-7. doi: 10.1073/pnas.70.2.535.
Abstract
We propose a structure for the genome of Drosophila melanogaster in which each chromatid of each chromomere (band) consists on the average of about 30-35 different sequences of single-copy (unique) DNA, each on the average about 750 base pairs in length. These are separated from one another by stretches of the middle repetitive (reiterated) DNA, which in D. melanogaster makes up about 15% of the genome. These stretches are about 100-150 base pairs in length and are all of the same sequence or family in each individual chromomere and of a different family (sequence) in each different chromomere. Our proposed structure of the Drosophila genome is in accord with all of the known facts concerning the physical chemistry and molecular biology of Drosophila DNA.
摘要
我们提出了一种黑腹果蝇基因组结构，其中每个染色粒（带）的每条染色单体平均由约30 - 35个不同的单拷贝（独特）DNA序列组成，每个序列平均长度约为750个碱基对。它们被中间重复（ reiterated ）DNA片段彼此隔开，在黑腹果蝇中，这些片段约占基因组的15%。这些片段长度约为100 - 150个碱基对，在每个单独的染色粒中都是相同的序列或家族，而在每个不同的染色粒中则是不同的家族（序列）。我们提出的果蝇基因组结构与关于果蝇DNA物理化学和分子生物学的所有已知事实相符。
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1
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2
Formation of duplication-deficiency products by asymmetrical exchange within a complex locus of Drosophila melanogaster.通过黑腹果蝇复杂基因座内的不对称交换形成重复-缺失产物。
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3
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J Mol Biol. 1970 Apr 28;49(2):381-91. doi: 10.1016/0022-2836(70)90251-2.
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