七个欧洲国家甲型肝炎抗体情况。I. 不同年龄组患病率数据比较

Antibody against hepatitis A in seven European countries. I. Comparison of prevalence data in different age groups.

作者信息

Frösner G G, Papaevangelou G, Bütler R, Iwarson S, Lindholm A, Couroucé-Pauty A, Haas H, Deinhardt F

出版信息

Am J Epidemiol. 1979 Jul;110(1):63-9. doi: 10.1093/oxfordjournals.aje.a112788.

DOI:10.1093/oxfordjournals.aje.a112788

Abstract

Using a solid phase radioimmunoassay, antibody to hepatitis A virus (anti-HAV) was determined in 3890 sera from populations in seven European countries. Prevalence of anti-HAV was lowest in Scandinavian countries and highest in Greece and France. Antibodies were found in 77 (13%) of 602 blood donors in Sweden, in 29 (17%) of 175 blood donors and women taking birth control pills in Norway, in 273 (39%) of 700 blood donors in Switzerland, in 262 (52%) of 505 blood donors in Holland, in 365 (55%) of 661 accident patients in West Germany, in 452 (75%) of 600 blood donors in France and in 530 (82%) of 647 persons in Greece. Prevalence of anti-HAV increased with age in all populations tested, indicating nearly total exposure to HAV in persons over 19 years of age in Greece and in persons over 39 years of age in West Germany, Holland and France. Antibody was found more frequently in rural than in urban populations in Greece and Switzerland. Calculation of the age-specific incidence of HAV infections suggests a remarkable decline in the exposure rate in the last few decades.

摘要

采用固相放射免疫分析法，对来自七个欧洲国家人群的3890份血清进行了甲型肝炎病毒抗体（抗-HAV）检测。抗-HAV的流行率在斯堪的纳维亚国家最低，在希腊和法国最高。在瑞典602名献血者中有77人（13%）检测到抗体，在挪威175名献血者和服用避孕药的女性中有29人（17%）检测到抗体，在瑞士700名献血者中有273人（39%）检测到抗体，在荷兰505名献血者中有262人（52%）检测到抗体，在西德661名事故患者中有365人（55%）检测到抗体，在法国600名献血者中有452人（75%）检测到抗体，在希腊647人中有530人（82%）检测到抗体。在所有检测人群中，抗-HAV的流行率均随年龄增长而升高，这表明希腊19岁以上人群以及西德、荷兰和法国39岁以上人群几乎全部接触过甲型肝炎病毒。在希腊和瑞士，农村人群中检测到抗体的频率高于城市人群。对甲型肝炎病毒感染年龄别发病率的计算表明在过去几十年中接触率显著下降。