磷脂对石棉溶血作用的抑制
Inhibition by phospholipids of haemolytic action of asbestos.
作者信息
Jaurand M C, Magne L, Bignon J
出版信息
Br J Ind Med. 1979 May;36(2):113-6. doi: 10.1136/oem.36.2.113.
Abstract
Haemolysis by asbestos fibres results from an increase in membrane permeability and not from rupture of red blood cells (RBC). The effect of chrysotile asbestos on RBC is at least partly, if not completely, attributable to lipid extraction and adsorption on to the fibres. This was suggested by the hyperbolic relationship between the haemolytic activity of chrysotile and the relative concentration of both chrysotile and RBC. Moreover, it was shown that pre-incubation of chrysotile with lipids, either as RBC membranes or with pure lipids in the form of liposomes, prevents haemolysis.
摘要
石棉纤维引起的溶血是由于膜通透性增加，而非红细胞破裂所致。温石棉对红细胞的影响即使不是完全归因于脂质提取和纤维吸附，至少也是部分归因于此。温石棉的溶血活性与温石棉和红细胞的相对浓度之间呈双曲线关系，这表明了这一点。此外，研究表明，将温石棉与脂质（无论是红细胞膜形式还是脂质体形式的纯脂质）预孵育可防止溶血。
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引用本文的文献
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