Spagna V A, Prior R B, Perkins R L
Br J Vener Dis. 1979 Jun;55(3):179-82. doi: 10.1136/sti.55.3.179.
In an evaluation of the limulus assay as a method for detecting endotoxin in urethral exudates, positive results of urethral samples at a 1/200 dilution were obtained from 73 out of 73 patients with culture-positive gonococcal urethritis while negative results were obtained from 26 out of 27 patients with cuture-negative urethral specimens. A specimen from one patient, which gave negative results on Gram stain and culture, gave positive results to the limulus test. The overall accuracy of the limulus test for predicting culture results was 99% (p less than 0.001). Thus, in preliminary studies of otherwise healthy men, the results of the limulus assay correlated with those of biological methods for diagnosing urethral gonorrhoea; the test may, therefore, be of use in identifying cases of nongonococcal urethritis.
在一项将鲎试剂检测法作为检测尿道渗出物中内毒素的方法的评估中，73例培养阳性的淋菌性尿道炎患者的尿道样本在稀释至1/200时，鲎试剂检测结果均为阳性；而27例培养阴性的尿道标本患者中，有26例检测结果为阴性。1例患者的标本革兰氏染色和培养结果均为阴性，但鲎试剂检测结果为阳性。鲎试剂检测法预测培养结果的总体准确率为99%（p<0.001）。因此，在对健康男性的初步研究中，鲎试剂检测结果与诊断尿道淋病的生物学方法的结果相关；因此，该检测方法可能有助于识别非淋菌性尿道炎病例。
