Nakhla L S, Goggin M J
Immunology. 1973 Feb;24(2):229-35.
The transformation of cultured lymphocytes in response to stimulation by phytohaemagglutinin (PHA) and purified protein derivative (PPD) in nineteen patients with chronic renal failure and four normal controls was studied. This was significantly lower in the patients than in the controls in response to both stimulants. Among the patients those with blood urea level higher than 200 mg/ml showed a transformation rate significantly higher than those with lower levels of blood urea in response to PHA. Mean values of transformation rate were lower in patients of the older age group (>50 years) and in the more chronic cases (>5 years) but the differences were not statistically significant.
研究了19例慢性肾功能衰竭患者和4名正常对照者的培养淋巴细胞对植物血凝素（PHA）和纯化蛋白衍生物（PPD）刺激的反应。在对两种刺激物的反应中，患者的反应明显低于对照组。在患者中，血尿素水平高于200mg/ml的患者对PHA的转化率明显高于血尿素水平较低的患者。老年组（>50岁）和病程较长（>5年）的患者转化率平均值较低，但差异无统计学意义。
