屈光不正的遗传模式。
Modes of inheritance of errors of refraction.
作者信息
Sorsby A, Benjamin B
出版信息
J Med Genet. 1973 Jun;10(2):161-4. doi: 10.1136/jmg.10.2.161.
Eighteen families in which both parents had refractions within the range of +4·0 D to −4·0 D and axial lengths seen in emmetropia (22·3-26·0 mm) showed coefficients of correlation of the order 0·5 indicative of polygenic inheritance. Such coefficients were seen for axial length (0·407) and for the cornea (0·487), but not for the lens (which is known to be yoked to the axial length). No such coefficients were seen in 19 families in which one of the parents had axial length outside the emmetropic range (nine families with long axes and 10 with short axes). The pattern of polygenic inheritance for emmetropia (completely correlated optical components) and errors of refraction up to 4·0 D (inadequately correlated components: correlation ametropia) follows that seen in stature and other measurable characters. In contrast the high refractive errors with their abnormal axial lengths (component ametropia) are—like the extremes in stature—pathological anomalies with monofactorial inheritance.
18个家庭中，父母双方的屈光度在+4.0 D至−4.0 D范围内，眼轴长度处于正视眼所见范围（22.3 - 26.0毫米），其相关系数约为0.5，表明为多基因遗传。眼轴长度（0.407）和角膜（0.487）呈现出这样的系数，但晶状体（已知与眼轴长度相关）则未出现。在19个家庭中，父母一方的眼轴长度超出正视范围（9个家庭眼轴长，10个家庭眼轴短），未观察到此类系数。正视眼（完全相关的光学组件）和屈光度高达4.0 D的屈光不正（不完全相关的组件：相关屈光不正）的多基因遗传模式与身高及其他可测量特征的模式相似。相比之下，具有异常眼轴长度的高度屈光不正（组件性屈光不正）——就像身高的极端情况一样——是单基因遗传的病理异常。
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