大鼠离体肺肺循环中去甲肾上腺素的清除
The removal of noradrenaline in the pulmonary circulation of rat isolated lungs.
作者信息
Alabaster V A, Bakhle Y S
出版信息
Br J Pharmacol. 1973 Feb;47(2):325-31. doi: 10.1111/j.1476-5381.1973.tb08330.x.
Abstract
- Removal of noradrenaline by isolated lungs of the rat, perfused via the pulmonary artery with Krebs bicarbonate solution has been studied.2. A constant removal (40.2%) was observed over a concentration range of 2-50 ng noradrenaline/ml (12-300 nM). At 100 ng/ml (600 nM), the removal is significantly reduced to 33.5%.3. The removal of noradrenaline was inhibited by cocaine (1 muM), but not by normetanephrine (5 muM), metaraminol (10 muM), phenoxybenzamine (10 muM) and 5-hydroxytryptamine (110 and 560 nM).4. We conclude that the removal of noradrenaline in the lungs does not involve an uptake process comparable with those previously described for this amine. The uptake process for noradrenaline in the lung is similar to that for 5-hydroxytryptamine and may be unique to this tissue.
摘要
研究了通过肺动脉用 Krebs 碳酸氢盐溶液灌注的大鼠离体肺对去甲肾上腺素的清除情况。
在 2 - 50 ng 去甲肾上腺素/毫升（12 - 300 nM）的浓度范围内观察到恒定的清除率（40.2%）。在 100 ng/毫升（600 nM）时，清除率显著降低至 33.5%。
可卡因（1 μM）可抑制去甲肾上腺素的清除，但去甲变肾上腺素（5 μM）、间羟胺（10 μM）、酚苄明（10 μM）和 5 - 羟色胺（110 和 560 nM）则无此作用。
我们得出结论，肺中去甲肾上腺素的清除不涉及与先前描述的该胺类摄取过程相当的过程。肺中去甲肾上腺素的摄取过程与 5 - 羟色胺的摄取过程相似，可能是该组织所特有的。
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The extraneuronal uptake and localization of noradrenaline in the cat spleen and the effect on this of some drugs, of cold and of denervation.去甲肾上腺素在猫脾脏中的神经元外摄取与定位以及某些药物、寒冷和去神经支配对此的影响。
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