Tolonen M, Nurminen M, Hernberg S
Scand J Work Environ Health. 1979 Jun;5(2):109-14. doi: 10.5271/sjweh.2662.
Two cohorts, one comprising 343 viscose rayon workers exposed for at least five years to carbon disulfide (CS2) and the other made up of 343 nonexposed men, were followed from 1967 to 1977 with respect to coronary heart disease (CHD) mortality. In the examination in 1967 known risk factors of CHD were controlled; only blood pressure was slightly higher in the exposed group. The difference was considered a result of exposure. Five exposed and eight nonexposed men had experienced a previous clinical myocardial infarction. The total mortality was 48 (14%) in the exposed group and 31 (9%) in the compeer group (p congruent to 0.05); 29 exposed and 11 nonexposed men had died from CHD (p less than 0.01), and 5 exposed and 1 nonexposed from other cardiovascular causes (p = 0.1). All coronary deaths occurred in the age interval 40 to 69 years. The estimated risk of death from CHD for this 30-year age span, assuming no competing risks of death, was 31.9% for the exposed cohort against 13.3% for the compeers. A multivariate analysis yielded age, raised blood pressure, and exposure to CS2 as prominent risk factors. The contributory risk caused by past occupational CS2 exposure seemed to increase the already notoriously high risk of CHD mortality among Finnish men.
两个队列，一个由343名至少接触二硫化碳（CS2）五年的粘胶纤维工人组成，另一个由343名未接触的男性组成，从1967年至1977年对冠心病（CHD）死亡率进行了随访。在1967年的检查中，对已知的冠心病风险因素进行了控制；仅暴露组的血压略高。这种差异被认为是暴露的结果。5名暴露组男性和8名未暴露组男性曾经历过临床心肌梗死。暴露组的总死亡率为48人（14%），对照组为31人（9%）（p约等于0.05）；29名暴露组男性和11名未暴露组男性死于冠心病（p小于0.01），5名暴露组男性和1名未暴露组男性死于其他心血管原因（p = 0.1）。所有冠心病死亡均发生在40至69岁年龄区间。假设无其他死亡竞争风险，该30年年龄跨度内暴露队列死于冠心病的估计风险为31.9%，而对照组为13.3%。多变量分析得出年龄、血压升高和接触CS2为主要风险因素。过去职业性接触CS2所致的促成风险似乎增加了芬兰男性中本已高得惊人的冠心病死亡风险。
