体外正常组织中癌样抗原的快速形成
Rapid development of a cancer-like antigen in normal tissue in vitro.
作者信息
Field E J, Hughes D, Caspary E A
出版信息
Br J Cancer. 1973 Jun;27(6):427-33. doi: 10.1038/bjc.1973.53.
Abstract
Freshly excised human embryonic tissue used as antigen to test lymphocytes from a cancer bearing patient gives a "normal tissue" result of about 10% in the macrophage electrophoresis migration (MEM) test. When, however, it is grown in vitro and then used as an antigenic stimulant to cancer lymphocytes, a "cancerlike" result (about 15%) is produced. These new antigenic determinant(s) akin to those associated with cancer basic protein appear rapidly (within 5.5 hours) in vitro. Cultures of "normal" cells are thus antigenically different from the same cells in context in vivo.
摘要
将刚切除的人类胚胎组织用作抗原，来检测癌症患者的淋巴细胞，在巨噬细胞电泳迁移（MEM）试验中会得到约10%的“正常组织”结果。然而，当该组织在体外培养，然后用作癌症淋巴细胞的抗原刺激物时，会产生“类癌”结果（约15%）。这些类似于与癌基础蛋白相关的新抗原决定簇在体外迅速（在5.5小时内）出现。因此，“正常”细胞的培养物在抗原性上与体内相同细胞不同。
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