Jokipii A M, Jokipii L
J Clin Pathol. 1973 Sep;26(9):687-90. doi: 10.1136/jcp.26.9.687.
The relationship between the intensity of the delayed hypersensitivity reaction and the dose of antigen used for its elicitation change with time after sensitization. At three weeks the reactions to 100 mug of egg albumen were little different from those to 1 mug but at 14 weeks 100 mug gave much stronger reactions. This means that to follow the development of a delayed hypersensitivity response several antigen doses should be used. If two skin tests were performed simultaneously in the same individual, the stronger one suppressed the weaker one, regardless of whether two different doses of the same antigen or two different antigens were used. Consequently, not more than one skin test at a time should be performed.
迟发型超敏反应的强度与用于引发该反应的抗原剂量之间的关系会随着致敏后的时间而变化。在三周时，对100微克蛋清的反应与对1微克的反应差异不大，但在14周时，100微克引发的反应要强得多。这意味着为了追踪迟发型超敏反应的发展，应该使用几种不同剂量的抗原。如果在同一个体中同时进行两次皮肤试验，无论使用的是同一抗原的两种不同剂量还是两种不同抗原，较强的一次会抑制较弱的一次。因此，一次不应进行超过一次皮肤试验。
