α-银环蛇毒素对乙酰胆碱受体的作用。
The effect of alpha-bungarotoxin on acetylcholine receptors.
作者信息
Katz B, Miledi R
出版信息
Br J Pharmacol. 1973 Sep;49(1):138-9. doi: 10.1111/j.1476-5381.1973.tb08278.x.
Abstract
Fluctuations of membrane potential ('membrane noise') during acetylcholineinduced depolarization have been studied by intracellular recording from endplates of frog muscle fibres. When acetylcholine sensitivity had been greatly reduced by an irreversible inhibitor (alpha-bungarotoxin), analysis of the membrane noise showed that neither the amplitude nor the time course of the 'elementary' potential change (due to the molecular depolarizing action of acetylcholine) were altered.
摘要
通过对蛙肌纤维终板进行细胞内记录，研究了乙酰胆碱诱导去极化过程中膜电位的波动（“膜噪声”）。当用不可逆抑制剂（α-银环蛇毒素）使乙酰胆碱敏感性大大降低时，对膜噪声的分析表明，“基本”电位变化（由于乙酰胆碱的分子去极化作用）的幅度和时间进程均未改变。
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本文引用的文献
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ISOLATION OF NEUROTOXINS FROM THE VENOM OF BUNGARUS MULTICINCTUS AND THEIR MODES OF NEUROMUSCULAR BLOCKING ACTION.从银环蛇毒液中分离神经毒素及其神经肌肉阻断作用方式
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Membrane noise produced by acetylcholine.乙酰胆碱产生的膜噪声。
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Acetylcholine receptors in muscle fibres.肌纤维中的乙酰胆碱受体。
Nature. 1971 Oct 29;233(5322):599-603. doi: 10.1038/233599a0.
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