抗体特异性的遗传。II. 小鼠中的抗（4-羟基-5-溴-3-硝基苯基）乙酰基
Inheritance of antibody specificity. II. Anti-(4-hydroxy-5-bromo-3-nitrophenyl) acetyl in the mouse.
作者信息
Imanishi T, Makela O
出版信息
J Exp Med. 1975 Apr 1;141(4):840-54.
Mice of 17 inbred strains produced anti-(4-hydroxy-5-bromo-3-nitrophenyl)-acetyl (NBrP) of three different fine specificity types. Anti-NBrP antibodies of all allotype b mice (five strains tested) had a high relative affinity for (4-hydroxy-3.5-dinitrophenyl) acetyl (NNP) but low for (4-hydroxy-5-cloro-3-nitrophenyl) acetyl (NCP). Another category was characterized by high relative affinity for NCP but low for NNP. This category included most of the tested strains. The third category (CBA and C3H strains) had an intermediate fine specificity. Associated with fine specificity characteristics were anti-NBrP titers, mice of allotype b had lower titers than the other mice. Studies of congenic, recombinant inbred, F1 and backcross mice showed that both fine specificity and the magnitude of the anti-NBrP response of tbalb/C MICE WERE CONTROLLED BY AN ALLOTYPE-LINKED GENE. This gene was dominant over the C57BL/6 ALLELE. Lack of recombinant mice in the backcross generatioterns on the other suggest close linkage between the two genes.
17个近交系小鼠产生了三种不同精细特异性类型的抗（4-羟基-5-溴-3-硝基苯基）乙酰基（NBrP）抗体。所有同种异型b小鼠（测试了5个品系）的抗NBrP抗体对（4-羟基-3,5-二硝基苯基）乙酰基（NNP）具有高相对亲和力，但对（4-羟基-5-氯-3-硝基苯基）乙酰基（NCP）的亲和力较低。另一类的特征是对NCP具有高相对亲和力，但对NNP的亲和力较低。这一类包括大多数测试品系。第三类（CBA和C3H品系）具有中等精细特异性。与精细特异性特征相关的是抗NBrP滴度，同种异型b小鼠的滴度低于其他小鼠。对同源、重组近交、F1和回交小鼠的研究表明，tbalb/C小鼠的抗NBrP反应的精细特异性和强度均由一个与同种异型相关的基因控制。该基因对C57BL/6等位基因呈显性。回交后代中缺乏重组小鼠这一情况表明这两个基因之间存在紧密连锁。
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