抗体合成控制的研究。十二。遗传对抗体亲和力的影响。
Studies on the control of antibody synthesis. XII. Genetic influences on antibody affinity.
作者信息
Kim Y T, Siskind G W
出版信息
Immunology. 1978 Apr;34(4):669-78.
Abstract
Genetic controls on the concentration and affinity of the anti-dinitrophenyl antibodies produced by different inbred strains of mice in response to immunization with dinitrophenylated bovine gamma globulin in Freund's complete adjuvant were demonstrated. Based upon data on F1 hybrids and backcrosses, it can be concluded that there are genetic controls on antibody affinity which are not linked to the major histocompatibility complex. In addition, the genetic controls on affinity which were studied here appear to be inherited independently of genetic controls on antibody concentration.
摘要
已证明，不同近交系小鼠在弗氏完全佐剂中用二硝基苯基化牛γ球蛋白免疫后产生的抗二硝基苯基抗体的浓度和亲和力存在遗传控制。基于关于F1杂种和回交的数据，可以得出结论，抗体亲和力存在遗传控制，且与主要组织相容性复合体无关。此外，此处研究的亲和力遗传控制似乎独立于抗体浓度的遗传控制而遗传。
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General methods for the study of cells and serum during the immune response: the response to dinitrophenyl in mice.免疫反应过程中细胞与血清研究的一般方法：小鼠对二硝基苯基的反应
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