诱导对抗体介导的细胞毒性的抗性。H-2、Ia和Ig抗原是小鼠淋巴细胞膜中的独立实体。
Induction of resistance to antibody-mediated cytotoxicity. H-2, Ia, and Ig antigens are independent entities in the membrane of mouse lymphocytes.
作者信息
Hauptfeld V, Hauptfeld M, Klein J
出版信息
J Exp Med. 1975 May 1;141(5):1047-56. doi: 10.1084/jem.141.5.1047.
Abstract
Mouse spleen or thymus lymphocytes incubated with monospecific H-2 or Ia alloantisera and then coated with a xenogeneic antimouse Ig serum become specifically resistant to the alloantiserum (and complement) they have been incubated with. This so called "lysostrip method" was used to investigate the molecular interrelationships of antigens in the mouse lymphocyte membrane. The results of this investigation confirm that H-2K and H-2D antigens are carried by two distinct populations of molecules. They provide evidence that the Ia antigens move in the membrane independently of both H2-K and H-2D antigens; and finally they demonstrate absence of any physical linkage between Ig receptors in B cells, on the one hand, and Ia, H-2K, and H-2D molecules on the other hand.
摘要
将小鼠脾脏或胸腺淋巴细胞与单特异性H-2或Ia同种异体抗血清一起孵育，然后用异种抗小鼠Ig血清包被，这些细胞会对它们所孵育的同种异体抗血清（和补体）产生特异性抗性。这种所谓的“溶菌去除法”被用于研究小鼠淋巴细胞膜中抗原的分子相互关系。该研究结果证实，H-2K和H-2D抗原由两个不同的分子群体携带。它们提供了证据表明Ia抗原在膜中独立于H2-K和H-2D抗原移动；最后，它们证明了一方面B细胞中的Ig受体与另一方面的Ia、H-2K和H-2D分子之间不存在任何物理联系。
相似文献
1
Induction of resistance to antibody-mediated cytotoxicity. H-2, Ia, and Ig antigens are independent entities in the membrane of mouse lymphocytes.诱导对抗体介导的细胞毒性的抗性。H-2、Ia和Ig抗原是小鼠淋巴细胞膜中的独立实体。
J Exp Med. 1975 May 1;141(5):1047-56. doi: 10.1084/jem.141.5.1047.
2
Interactions of Fc receptors with antibodies against Ia antigens and other cell surface components.Fc受体与抗Ia抗原及其他细胞表面成分抗体的相互作用。
J Exp Med. 1975 May 1;141(5):1201-9. doi: 10.1084/jem.141.5.1201.
3
Immunoglobulin and other surface antigens of cells of the immune system.免疫系统细胞的免疫球蛋白及其他表面抗原。
J Exp Med. 1971 Oct 1;134(4):815-32. doi: 10.1084/jem.134.4.815.
4
Independence of H-2K and H-2D antigenic determinants on the surface of mouse lymphocytes.小鼠淋巴细胞表面H-2K和H-2D抗原决定簇的独立性
J Exp Med. 1973 Feb 1;137(2):511-26. doi: 10.1084/jem.137.2.511.
5
A new sensitive assay for antibody against cell surface antigens based on inhibition of cell-dependent antibody-mediated cytotoxicity. I. Specificity and sensitivity.一种基于抑制细胞依赖性抗体介导的细胞毒性的新型细胞表面抗原抗体敏感检测方法。I. 特异性和敏感性。
J Exp Med. 1974 Nov 1;140(5):1348-63. doi: 10.1084/jem.140.5.1348.
6
Beta-2-microglobulin. Part of the HL-A molecule in the cell membrane.β2微球蛋白。细胞膜中HL-A分子的一部分。
Tissue Antigens. 1974;4(1):83-94. doi: 10.1111/j.1399-0039.1974.tb00229.x.
7
8
Behaviour of mouse H-2 specificities on polyacrylamide gel electrophoresis and polyacrylamide gel electrofocussing.小鼠H-2特异性在聚丙烯酰胺凝胶电泳和聚丙烯酰胺凝胶聚焦中的行为。
Biochim Biophys Acta. 1971 Aug 27;243(2):337-42. doi: 10.1016/0005-2795(71)90092-4.
9
Ia antigens on murine thymocytes: detection by cellular radioimmunoassay.小鼠胸腺细胞上的Ia抗原：通过细胞放射免疫测定法进行检测。
J Immunol. 1977 Mar;118(3):998-1003.
10
A specific mouse B lymphocyte antigen (MBLA) demonstrated by double immunofluorescence.通过双重免疫荧光法证实的一种特异性小鼠B淋巴细胞抗原（MBLA）。
J Immunol. 1972 Aug;109(2):366-70.
引用本文的文献
1
Mouse mitochondrial superoxide dismutase locus is on chromosome 17.小鼠线粒体超氧化物歧化酶基因座位于17号染色体上。
Immunogenetics. 1981;14(3-4):231-40. doi: 10.1007/BF00342192.
2
Augmentation of antibody-dependent cell-mediated cytotoxicity by anti-immunoglobulin. I. Relationship to target cell capping.抗免疫球蛋白增强抗体依赖性细胞介导的细胞毒性。I. 与靶细胞封帽的关系。
Clin Exp Immunol. 1980 Oct;42(1):127-35.
3
Gene(s) affecting the expression of Qa-1.影响Qa-1表达的基因
Immunogenetics. 1982;16(5):435-44. doi: 10.1007/BF00372102.
4
Serological characterization of previously unknown H-2 molecules identified in the products of the Kd and Dk region.对在Kd和Dk区域产物中鉴定出的此前未知的H-2分子进行血清学鉴定。
Immunogenetics. 1981;12(3-4):397-408. doi: 10.1007/BF01561679.
5
The partial amino-acid sequence of an H-2K molecule.一种H-2K分子的部分氨基酸序列。
Proc Natl Acad Sci U S A. 1976 Mar;73(3):905-9. doi: 10.1073/pnas.73.3.905.
6
A new antigen system expressed in human endothelial cells.一种在人内皮细胞中表达的新抗原系统。
J Clin Invest. 1977 Aug;60(2):449-54. doi: 10.1172/JCI108795.
7
The localization of allogeneic lymphoid cells in relation to antibody-mediated immunosuppression.同种异体淋巴细胞的定位与抗体介导的免疫抑制的关系。
Immunology. 1979 Mar;36(3):533-8.
8
Primary in vitro cell-mediated lympholysis reaction of NZB mice against unmodified targets syngeneic at the major histocompatibility complex.新西兰黑小鼠针对主要组织相容性复合体同基因未修饰靶标的原发性体外细胞介导的淋巴细胞溶解反应。
J Exp Med. 1978 May 1;147(5):1435-48. doi: 10.1084/jem.147.5.1435.
9
Molecular relationship between private and public H-2 antigens as determined by antigen redistribution method.通过抗原再分布法确定的私有和公共H-2抗原之间的分子关系。
J Exp Med. 1975 Aug 1;142(2):288-98. doi: 10.1084/jem.142.2.288.
本文引用的文献
1
THE AKR THYMIC ANTIGEN AND ITS DISTRIBUTION IN LEUKEMIAS AND NERVOUS TISSUES.AKR胸腺抗原及其在白血病和神经组织中的分布。
J Exp Med. 1964 Sep 1;120(3):413-33. doi: 10.1084/jem.120.3.413.
2
A simple micro cytotoxicity test.一种简单的微量细胞毒性试验。
Transplantation. 1969 Mar;7(3):220-3. doi: 10.1097/00007890-196903000-00023.
3
Antigenic modulation in vitro. I. Fate of thymus-leukemia (TL) antigen-antibody complexes following modulation of TL antigenicity from the surfaces of mouse leukemia cells and thymocytes.体外抗原调制。I. 从小鼠白血病细胞和胸腺细胞表面调制TL抗原性后胸腺白血病（TL）抗原-抗体复合物的命运。
J Exp Med. 1974 Oct 1;140(4):939-53. doi: 10.1084/jem.140.4.939.
4
Tissue distribution of I region-associated antigens in the mouse.小鼠中I区相关抗原的组织分布
J Immunol. 1974 Jul;113(1):181-8.
5
Serological identification of an Ir-region product.Ir区域产物的血清学鉴定。
Science. 1973 Jul 13;181(4095):167-9. doi: 10.1126/science.181.4095.167.
6
New lymphocyte antigen system (Lna) controlled by the Ir region of the mouse H-2 complex.由小鼠H-2复合体的Ir区域控制的新淋巴细胞抗原系统（Lna）。
Proc Natl Acad Sci U S A. 1973 Sep;70(9):2509-14. doi: 10.1073/pnas.70.9.2509.
7
The fluid mosaic model of the structure of cell membranes.细胞膜结构的流动镶嵌模型。
Science. 1972 Feb 18;175(4023):720-31. doi: 10.1126/science.175.4023.720.
8
Membrane molecules determined by the H-2 associated immune response region: isolation and some properties.由H-2相关免疫反应区决定的膜分子：分离及其某些特性
Proc Natl Acad Sci U S A. 1974 Mar;71(3):648-52. doi: 10.1073/pnas.71.3.648.
9
Fate of HL-A antigens and antibodies at the lymphocyte surface.淋巴细胞表面HL-A抗原和抗体的命运
Transplant Proc. 1973 Dec;5(4):1835-47.
10
A mouse B-cell alloantigen determined by gene(s) linked to the major histocompatibility complex.一种由与主要组织相容性复合体连锁的基因所决定的小鼠B细胞同种抗原。
J Exp Med. 1973 Dec 1;138(6):1289-304. doi: 10.1084/jem.138.6.1289.
Zotero 插件