对磷酸胆碱（PC）免疫应答的克隆性质。V. 小鼠抗PC抗体重链与PC结合骨髓瘤蛋白之间的交叉独特型特异性。
Clonal nature of the immune response to phosphorylcholine (PC). V. Cross-idiotypic specificity among heavy chains of murine anti-PC antibodies and PC-binding myeloma proteins.
作者信息
Claflin J L, Davie J M
出版信息
J Exp Med. 1975 May 1;141(5):1073-83. doi: 10.1084/jem.141.5.1073.
Abstract
Seven mouse myeloma proteins with specificity for phosphorylcholine (PC) were found to share a common antigenic determinant. This group of proteins contained members which differed in genetic origin, heavy chain class, kappa-chain subgroup, individual antigenic determinants and specificity for choline analogues. The cross-idiotypic determinant, VH-PC, was antigenically similar in each of the proteins and was associated with the variable portion of the heavy chain in the region of the antibody combining site. Further studies showed that an indistinguishable determinant was present on IgM anti-PC antibodies isolated from all strains of mice tested regardless of histocompatibility or heavy chain allotype. In view of the finding that this cross-idiotypic determinant was not found on antibodies or myeloma proteins which lacked specificity for PC, the data strongly suggest that a particular heavy chain variable region has been preserved in all mouse antibodies with specificity for PC.
摘要
发现七种对磷酸胆碱（PC）具有特异性的小鼠骨髓瘤蛋白具有共同的抗原决定簇。这组蛋白包含在遗传起源、重链类别、κ链亚组、个体抗原决定簇以及对胆碱类似物的特异性方面存在差异的成员。交叉独特型决定簇VH-PC在每种蛋白中抗原性相似，并且与抗体结合部位区域重链的可变部分相关。进一步的研究表明，从所有测试的小鼠品系中分离出的IgM抗PC抗体上存在无法区分的决定簇，无论其组织相容性或重链同种异型如何。鉴于在缺乏对PC特异性的抗体或骨髓瘤蛋白上未发现这种交叉独特型决定簇这一发现，数据强烈表明，在所有对PC具有特异性的小鼠抗体中都保留了一个特定的重链可变区。
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