Cookson B, Tripp J, Leung T, Williams J D
Infection. 1980;8 Suppl 3:S 239-42. doi: 10.1007/BF01639588.
The recommended neonatal dosage regime for amikacin of 15 mg/kg/day was found to be unsatisfactory in four neonates and a loading dose of 10 mg/kg did not improve levels in two further newborns with normal renal function. Fourteen neonates on 20 mg/kg/day regime achieved satisfactory levels; peak values were 21.5 +/- 4.5 microgram/ml and trough levels 3.34 +/- 2.05 microgram/ml. Peak time ranged from 17 to 60 minutes and varied with the dose given. The half-life was related to plasma creatinine, urea, post-natal age and weight. Thirteen neonates with pre-existing renal impairment were managed by alteration of dosage interval or quantity given. Side-effects were confined to eosinophilia in six infants, and no definite nephrotoxicity or gross eighth nerve damage was demonstrated.
已发现，对于4名新生儿而言，推荐的阿米卡星新生儿剂量方案（15毫克/千克/天）并不令人满意，另外2名肾功能正常的新生儿在给予10毫克/千克的负荷剂量后，其血药浓度并未提高。14名接受20毫克/千克/天剂量方案的新生儿血药浓度达到了满意水平；峰值为21.5±4.5微克/毫升，谷值为3.34±2.05微克/毫升。达峰时间为17至60分钟，且随给药剂量而变化。半衰期与血肌酐、尿素、出生后年龄和体重有关。13名已有肾功能损害的新生儿通过改变给药间隔或给药量进行治疗。副作用仅限于6名婴儿出现嗜酸性粒细胞增多，未发现明确的肾毒性或严重的第八对脑神经损伤。
