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从恶性肿瘤中分离出一种“抗原”。

Isolation of an "antigen" from malignant tumours.

作者信息

Carnegie P R, Caspary E A, Field E J

出版信息

Br J Cancer Suppl. 1973 Aug;1:219-23.

PMID:4804281
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2149041/
Abstract

From a variety of human malignant neoplasms it is possible to prepare by acid extraction and chromatography a fraction with peak “antigenic” activity in the macrophage electrophoretic mobility (MEM) test for cancer. The activity is related to the presence of tryptophan. An analysis of the most active material so far prepared suggests important differences from myelin basic protein and from histones.

摘要

从多种人类恶性肿瘤中，通过酸提取和色谱法有可能制备出一种在癌症巨噬细胞电泳迁移率（MEM）试验中具有“抗原”活性峰值的组分。该活性与色氨酸的存在有关。对迄今为止制备的活性最强的物质进行分析表明，它与髓鞘碱性蛋白和组蛋白存在重要差异。

相似文献

1
Isolation of an "antigen" from malignant tumours.从恶性肿瘤中分离出一种“抗原”。
Br J Cancer Suppl. 1973 Aug;1:219-23.
2
The chemical nature of cancer basic protein.癌症基础蛋白的化学性质。
Br J Cancer Suppl. 1973 Aug;1:224-8.
3
Isolation and identification of soluble skin-reactive membrane antigens of malignant and normal human breast cells.恶性和正常人类乳腺细胞可溶性皮肤反应性膜抗原的分离与鉴定。
Cancer Res. 1974 Nov;34(11):2961-8.
4
Use of the macrophage migration inhibition test to monitor fractionation of soluble antigens of chemically induced sarcomas of inbred guinea pigs.使用巨噬细胞游走抑制试验监测近交系豚鼠化学诱导肉瘤可溶性抗原的分级分离。
J Immunol. 1972 Oct;109(4):766-75.
5
Technical aspects of the macrophage electrophoretic mobility (MEM) test for malignant disease.用于恶性疾病的巨噬细胞电泳迁移率（MEM）检测的技术方面。
Br J Cancer Suppl. 1973 Aug;1:229-36.
6
The macrophage electrophoretic migration test in cancer.癌症中的巨噬细胞电泳迁移试验。
Clin Exp Immunol. 1973 Jul;14(3):469-72.
7
Macrophage electrophoretic mobility test for brain tumors and malignancies.用于脑肿瘤和恶性肿瘤的巨噬细胞电泳迁移率测试。
Chin Med J (Engl). 1979 Mar;92(3):211-5.
8
Role of immunity in diagnosis of human cancer. Discussion.免疫在人类癌症诊断中的作用。讨论。
Br J Cancer Suppl. 1973 Aug;1:237-42.
9
[Demonstration and characterization of tumor-associated antigenic components from cell membranes of a UV-induced murine sarcoma using the MEM technic].[使用MEM技术对紫外线诱导的小鼠肉瘤细胞膜上肿瘤相关抗原成分的演示与表征]
Acta Biol Med Ger. 1980;39(2-3):315-25.
10
Purification and partial characterization of nucleolar antigen-1 of the Novikoff hepatoma.诺维科夫肝癌核仁抗原-1的纯化及部分特性分析
Cancer Res. 1979 Jan;39(1):59-66.

引用本文的文献

1
Cell electrophoresis for diagnostic purposes. I. Diagnostic value of the electrophoretic mobility test (EMT) for the detection of gynaecological malignancies.用于诊断目的的细胞电泳。I. 电泳迁移率测试（EMT）在检测妇科恶性肿瘤中的诊断价值。
Br J Cancer. 1981 May;43(5):588-97. doi: 10.1038/bjc.1981.88.
2
Agglutination of peripheral blood lymphocytes from cancer patients and not from healthy controls, with the F2A1 histone fraction.癌症患者而非健康对照者的外周血淋巴细胞与F2A1组蛋白部分发生凝集。
Br J Cancer. 1975 Jul;32(1):28-33. doi: 10.1038/bjc.1975.130.
3
Usefulness of the SCM test in the diagnosis of gastric cancer.SCM试验在胃癌诊断中的应用价值。
Br J Cancer. 1977 Dec;36(6):810-3. doi: 10.1038/bjc.1977.266.
4
Changes in structuredness of cytoplasmic matrix in single stimulated lymphocytes from healthy donors and patients with non-malignant and malignant diseases.健康供体以及患有非恶性和恶性疾病患者的单个受刺激淋巴细胞中细胞质基质结构的变化。
Br J Cancer. 1979 Jul;40(1):156-60. doi: 10.1038/bjc.1979.152.
5
Immunological cross-reactivity between basic proteins of myelin and cancer. I. Lymphocyte transformation studies in immunized guinea-pigs.髓磷脂碱性蛋白与癌症之间的免疫交叉反应性。I. 免疫豚鼠的淋巴细胞转化研究。
Clin Exp Immunol. 1975 Oct;22(1):16-21.
6
[The electrophoretic-mobility-test (EMT) in the diagnosis of malignancies (author's transl)].[电泳迁移率试验（EMT）在恶性肿瘤诊断中的应用（作者译）]
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1976 Dec 9;87(3):281-90. doi: 10.1007/BF00506501.
7
Human tumour-associated and tumour-specific antigens: some concepts in relation to clinical oncology.人类肿瘤相关抗原和肿瘤特异性抗原：与临床肿瘤学相关的一些概念
J Clin Pathol Suppl (Assoc Clin Pathol). 1975;6:102-12. doi: 10.1136/jcp.s1-6.1.102.
8
Cellular immunity to encephalitogenic factor in man as measured by the macrophage migration inhibition test: the effects of serum.通过巨噬细胞移动抑制试验测定的人对致脑炎因子的细胞免疫：血清的影响。
Br J Cancer. 1978 Jan;37(1):15-22. doi: 10.1038/bjc.1978.2.
9
Responses of cancer patients in the MEM test: not just a function of charge on basic proteins.癌症患者在MEM测试中的反应：不仅仅是碱性蛋白质电荷的函数。
Br J Cancer. 1976 Jul;34(1):7-13. doi: 10.1038/bjc.1976.114.

本文引用的文献

1
Immunological activity of blood lymphocyte fractions. A study by the macrophage electrophoretic mobility method.血液淋巴细胞组分的免疫活性。巨噬细胞电泳迁移率法研究。
Clin Exp Immunol. 1972 Apr;10(4):571-9.
2
The macrophage electrophoretic migration (MEM) test for lymphocyte sensitization. A study of the kinetics.用于淋巴细胞致敏的巨噬细胞电泳迁移（MEM）试验。动力学研究。
Clin Exp Immunol. 1973 May;14(1):37-45.
3
Evaluation and development of the macrophage electrophoretic mobility (MEM) test for malignant disease.恶性疾病巨噬细胞电泳迁移率（MEM）检测的评估与开发。
Br J Cancer. 1973 Jan;27(1):1-9. doi: 10.1038/bjc.1973.1.
4
Allergic encephalomyelitis: cleavage of the C-tryptophyl bond in the encephalitogenic basic protein from bovne myelin.变应性脑脊髓炎：牛髓鞘致脑炎碱性蛋白中C-色氨酰键的裂解
Arch Biochem Biophys. 1969 Apr;131(1):215-22. doi: 10.1016/0003-9861(69)90124-6.
5
Localization of tumour specific antigen on external surface of plasma membrane.肿瘤特异性抗原在质膜外表面的定位。
Nat New Biol. 1972 Oct 11;239(93):181-3. doi: 10.1038/newbio239181a0.
6
Interaction of hallucinogenic drugs with encephalitogenic protein of myelin.致幻药物与髓磷脂致脑炎性蛋白的相互作用。
Nature. 1972 Dec 29;240(5383):561-3. doi: 10.1038/240561a0.
7
Macrophage-electrophoretic-mobility (M.E.M.) test for malignant disease. An independent confirmation.巨噬细胞电泳迁移率（M.E.M.）检测恶性疾病。一项独立验证。
Lancet. 1972 Sep 23;2(7778):627-9. doi: 10.1016/s0140-6736(72)93018-8.
8
Amino acid sequence of the encephalitogenic basic protein from human myelin.人髓磷脂致脑炎碱性蛋白的氨基酸序列。
Biochem J. 1971 Jun;123(1):57-67. doi: 10.1042/bj1230057.
9
Lymphocyte sensitization to basic protein of brain in malignant neoplasia: experiments with serotonin and related compounds.恶性肿瘤中淋巴细胞对脑碱性蛋白的致敏作用：血清素及相关化合物的实验
Nature. 1971 Sep 24;233(5317):284-6. doi: 10.1038/233284a0.
10
Specific lymphocyte sensitization in cancer: is there a common antigen in human malignant neoplasia?癌症中的特异性淋巴细胞致敏：人类恶性肿瘤中是否存在共同抗原？
Br Med J. 1971 Jun 12;2(5762):613-7. doi: 10.1136/bmj.2.5762.613.