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1
Immunological cross-reactivity between basic proteins of myelin and cancer. I. Lymphocyte transformation studies in immunized guinea-pigs.髓磷脂碱性蛋白与癌症之间的免疫交叉反应性。I. 免疫豚鼠的淋巴细胞转化研究。
Clin Exp Immunol. 1975 Oct;22(1):16-21.
2
Immunological cross-reactivity between acid extracts of myelin, liver and neoplastic tissues: studies in immunized guinea-pigs.髓磷脂、肝脏和肿瘤组织酸提取物之间的免疫交叉反应性：对免疫豚鼠的研究。
Br J Cancer. 1979 Sep;40(3):424-36. doi: 10.1038/bjc.1979.198.
3
Detection of antibodies to the basic protein of human myelin by radioimmunoassay and immunofluorescence.通过放射免疫测定法和免疫荧光法检测人髓磷脂碱性蛋白抗体。
J Immunol. 1971 Jul;107(1):56-62.
4
Induction of experimental autoimmune encephalomyelitis in Lewis rats by a viral peptide with limited homology to myelin basic protein.用与髓鞘碱性蛋白具有有限同源性的病毒肽诱导Lewis大鼠实验性自身免疫性脑脊髓炎。
Exp Neurol. 2007 Aug;206(2):231-9. doi: 10.1016/j.expneurol.2007.04.015. Epub 2007 May 24.
5
The antigenicity of myelin encephalitogenic protein: production of antibodies to encephalitogenic protein with deoxyribonucleic acid--encephalitogenic protein complexes.髓磷脂致脑炎蛋白的抗原性：利用脱氧核糖核酸-致脑炎蛋白复合物产生针对致脑炎蛋白的抗体。
J Immunol. 1975 Feb;114(2 pt 2):823-8.
6
Cell-mediated immunity in experimental allergic encephalomyelitis: cross reactivity between myelin basic protein and mycobacteria antigens.实验性变应性脑脊髓炎中的细胞介导免疫：髓鞘碱性蛋白与分枝杆菌抗原之间的交叉反应性。
Proc Soc Exp Biol Med. 1975 Apr;148(4):1233-6. doi: 10.3181/00379727-148-38723.
7
Cellular hypersensitivity to basic myelin (A1) protein and clinical multiple sclerosis.细胞对碱性髓鞘（A1）蛋白的超敏反应与临床多发性硬化症。
N Engl J Med. 1974 Jul 4;291(1):14-7. doi: 10.1056/NEJM197407042910104.
8
A rapid qualitative test for detection of precipitating antibody to myelin basic protein.一种用于检测髓鞘碱性蛋白沉淀抗体的快速定性试验。
Res Commun Chem Pathol Pharmacol. 1972 Nov;4(3):569-79.
9
Experimental autoimmune encephalomyelitis. Digestion of basic protein of human myelin with cyanogen bromide and trypsin.实验性自身免疫性脑脊髓炎。用溴化氰和胰蛋白酶消化人髓磷脂碱性蛋白。
Immunology. 1970 Jul;19(1):55-63.
10
Susceptibility and resistance to experimental autoimmune encephalomyelitis and neuritis in the guinea pig correlate with the induction of procoagulant and anticoagulant activities.豚鼠对实验性自身免疫性脑脊髓炎和神经炎的易感性及抗性与促凝血和抗凝血活性的诱导相关。
J Immunol. 1984 Dec;133(6):3026-36.

引用本文的文献

1
Cerebellar cortical degeneration with ovarian carcinoma.小脑皮质变性伴卵巢癌
Postgrad Med J. 1982 Jan;58(675):47-51. doi: 10.1136/pgmj.58.675.47.
2
Cell-mediated immunity to encephalitogenic factor (MMI test) in women with cervical dysplasia and carcinoma in situ: the effects of serum.宫颈发育异常和原位癌女性对致脑炎因子的细胞介导免疫（MMI试验）：血清的影响
Br J Cancer. 1978 Sep;38(3):396-400. doi: 10.1038/bjc.1978.220.
3
Failure to induce transplantation immunity to an SV40-induced tumour in hamsters immunized with basic proteins of myelin or malignant tissues.在用髓磷脂碱性蛋白或恶性组织免疫的仓鼠中，未能诱导出对SV40诱导肿瘤的移植免疫。
Br J Cancer. 1978 Jul;38(1):151-3. doi: 10.1038/bjc.1978.176.
4
Cellular immunity to encephalitogenic factor in man as measured by the macrophage migration inhibition test: the effects of serum.通过巨噬细胞移动抑制试验测定的人对致脑炎因子的细胞免疫：血清的影响。
Br J Cancer. 1978 Jan;37(1):15-22. doi: 10.1038/bjc.1978.2.
5
Responses of cancer patients in the MEM test: not just a function of charge on basic proteins.癌症患者在MEM测试中的反应：不仅仅是碱性蛋白质电荷的函数。
Br J Cancer. 1976 Jul;34(1):7-13. doi: 10.1038/bjc.1976.114.

本文引用的文献

1
Radioimmunoassay with gel filtration for detecting antibody to basic proteins of myelin.采用凝胶过滤的放射免疫测定法检测髓鞘碱性蛋白抗体。
J Lab Clin Med. 1968 Nov;72(5):824-31.
2
The mechanism of antigen-induced electrophoretic mobility reduction of guinea-pig macrophages.豚鼠巨噬细胞抗原诱导的电泳迁移率降低的机制。
Clin Exp Immunol. 1972 Jun;11(2):305-9.
3
Isolation of an "antigen" from malignant tumours.从恶性肿瘤中分离出一种“抗原”。
Br J Cancer Suppl. 1973 Aug;1:219-23.
4
A common tumour specific antigen. I. Restriction in vivo to malignant neoplastic tissue.一种常见的肿瘤特异性抗原。I. 在体内对恶性肿瘤组织的局限性
Br J Cancer. 1973 Feb;27(2):99-105. doi: 10.1038/bjc.1973.13.
5
The macrophage electrophoretic migration (MEM) test for lymphocyte sensitization. A study of the kinetics.用于淋巴细胞致敏的巨噬细胞电泳迁移（MEM）试验。动力学研究。
Clin Exp Immunol. 1973 May;14(1):37-45.
6
Lymphocytes binding basic protein of myelin; cytophilic serum antibody and effect of adjuvant.淋巴细胞与髓磷脂碱性蛋白结合；亲细胞血清抗体及佐剂的作用。
Immunology. 1973 Mar;24(3):425-34.
7
Evaluation and development of the macrophage electrophoretic mobility (MEM) test for malignant disease.恶性疾病巨噬细胞电泳迁移率（MEM）检测的评估与开发。
Br J Cancer. 1973 Jan;27(1):1-9. doi: 10.1038/bjc.1973.1.
8
Large scale preparation of myelin basic protein from central nervous tissue of several mammalian species.从几种哺乳动物的中枢神经组织中大规模制备髓鞘碱性蛋白。
Prep Biochem. 1972;2(2):139-65. doi: 10.1080/00327487208061467.
9
Histones and cancer test.组蛋白与癌症检测。
Nature. 1973 Sep 14;245(5420):98-9. doi: 10.1038/245098a0.
10
Depression of cell-mediated immunity in old age and the immunopathic diseases, lupus erythematosus, chronic hepatitis and rheumatoid arthritis.老年时细胞介导免疫的抑制与免疫性疾病、红斑狼疮、慢性肝炎及类风湿性关节炎。
Clin Exp Immunol. 1973 Jun;14(2):193-202.

髓磷脂碱性蛋白与癌症之间的免疫交叉反应性。I. 免疫豚鼠的淋巴细胞转化研究。

Immunological cross-reactivity between basic proteins of myelin and cancer. I. Lymphocyte transformation studies in immunized guinea-pigs.

作者信息

Coates A S, Carnegie P R

出版信息

Clin Exp Immunol. 1975 Oct;22(1):16-21.

PMID:174853
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1538324/
Abstract

The studies described were designed to examine the question of cross-reactivity between basic protein of myelin and a basic protein common to many human tumours. The lymphocytes from guinea-pigs injected with acid extracts of human cancer tissue showed significant (P less than 0-01) tranformation on exposure to basic protein of human myelin. Conversely lymphocytes from guinea-pigs injected with basic protein of human myelin showed significant (P less than 0-01) transformation on exposure to the acid extracts of human cancer tissue. Lymphocytes from control non-injected guinea-pigs did not transform on exposure to either antigen. These findings demonstrate immunological cross-reactivity in guinea-pigs between basic proteins of human myelin and of human cancer tissue using an assay system other than the macrophage electrophoretic migration hitherto used to show this effect in man.

摘要

所描述的这些研究旨在探讨髓磷脂碱性蛋白与许多人类肿瘤所共有的一种碱性蛋白之间的交叉反应问题。用人类癌组织酸性提取物注射的豚鼠的淋巴细胞，在接触人类髓磷脂碱性蛋白时显示出显著（P小于0.01）的转化。相反，用人类髓磷脂碱性蛋白注射的豚鼠的淋巴细胞，在接触人类癌组织酸性提取物时显示出显著（P小于0.01）的转化。未注射的对照豚鼠的淋巴细胞在接触任何一种抗原时都不发生转化。这些发现表明，使用一种不同于迄今用于在人类中显示这种效应的巨噬细胞电泳迁移分析系统，豚鼠体内人类髓磷脂碱性蛋白与人类癌组织碱性蛋白之间存在免疫交叉反应。