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髓磷脂碱性蛋白与癌症之间的免疫交叉反应性。I. 免疫豚鼠的淋巴细胞转化研究。

Immunological cross-reactivity between basic proteins of myelin and cancer. I. Lymphocyte transformation studies in immunized guinea-pigs.

作者信息

Coates A S, Carnegie P R

出版信息

Clin Exp Immunol. 1975 Oct;22(1):16-21.

PMID:174853
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1538324/
Abstract

The studies described were designed to examine the question of cross-reactivity between basic protein of myelin and a basic protein common to many human tumours. The lymphocytes from guinea-pigs injected with acid extracts of human cancer tissue showed significant (P less than 0-01) tranformation on exposure to basic protein of human myelin. Conversely lymphocytes from guinea-pigs injected with basic protein of human myelin showed significant (P less than 0-01) transformation on exposure to the acid extracts of human cancer tissue. Lymphocytes from control non-injected guinea-pigs did not transform on exposure to either antigen. These findings demonstrate immunological cross-reactivity in guinea-pigs between basic proteins of human myelin and of human cancer tissue using an assay system other than the macrophage electrophoretic migration hitherto used to show this effect in man.

摘要

所描述的这些研究旨在探讨髓磷脂碱性蛋白与许多人类肿瘤所共有的一种碱性蛋白之间的交叉反应问题。用人类癌组织酸性提取物注射的豚鼠的淋巴细胞，在接触人类髓磷脂碱性蛋白时显示出显著（P小于0.01）的转化。相反，用人类髓磷脂碱性蛋白注射的豚鼠的淋巴细胞，在接触人类癌组织酸性提取物时显示出显著（P小于0.01）的转化。未注射的对照豚鼠的淋巴细胞在接触任何一种抗原时都不发生转化。这些发现表明，使用一种不同于迄今用于在人类中显示这种效应的巨噬细胞电泳迁移分析系统，豚鼠体内人类髓磷脂碱性蛋白与人类癌组织碱性蛋白之间存在免疫交叉反应。

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本文引用的文献

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Radioimmunoassay with gel filtration for detecting antibody to basic proteins of myelin.采用凝胶过滤的放射免疫测定法检测髓鞘碱性蛋白抗体。
J Lab Clin Med. 1968 Nov;72(5):824-31.
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The mechanism of antigen-induced electrophoretic mobility reduction of guinea-pig macrophages.豚鼠巨噬细胞抗原诱导的电泳迁移率降低的机制。
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Isolation of an "antigen" from malignant tumours.从恶性肿瘤中分离出一种“抗原”。
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Br J Cancer. 1973 Feb;27(2):99-105. doi: 10.1038/bjc.1973.13.
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The macrophage electrophoretic migration (MEM) test for lymphocyte sensitization. A study of the kinetics.用于淋巴细胞致敏的巨噬细胞电泳迁移（MEM）试验。动力学研究。
Clin Exp Immunol. 1973 May;14(1):37-45.
6
Lymphocytes binding basic protein of myelin; cytophilic serum antibody and effect of adjuvant.淋巴细胞与髓磷脂碱性蛋白结合；亲细胞血清抗体及佐剂的作用。
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7
Evaluation and development of the macrophage electrophoretic mobility (MEM) test for malignant disease.恶性疾病巨噬细胞电泳迁移率（MEM）检测的评估与开发。
Br J Cancer. 1973 Jan;27(1):1-9. doi: 10.1038/bjc.1973.1.
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Large scale preparation of myelin basic protein from central nervous tissue of several mammalian species.从几种哺乳动物的中枢神经组织中大规模制备髓鞘碱性蛋白。
Prep Biochem. 1972;2(2):139-65. doi: 10.1080/00327487208061467.
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Histones and cancer test.组蛋白与癌症检测。
Nature. 1973 Sep 14;245(5420):98-9. doi: 10.1038/245098a0.
10
Depression of cell-mediated immunity in old age and the immunopathic diseases, lupus erythematosus, chronic hepatitis and rheumatoid arthritis.老年时细胞介导免疫的抑制与免疫性疾病、红斑狼疮、慢性肝炎及类风湿性关节炎。
Clin Exp Immunol. 1973 Jun;14(2):193-202.

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