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Superoxide dismutase activity in leukocytes.白细胞中的超氧化物歧化酶活性。
J Clin Invest. 1974 Apr;53(4):1197-201. doi: 10.1172/JCI107659.
2
Superoxide dismutases in polymorphonuclear leukocytes.多形核白细胞中的超氧化物歧化酶
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3
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Effect of phagocytosis on superoxide anion production and superoxide dismutase levels in BCG-activated and normal rabbit alveolar macrophages.吞噬作用对卡介苗激活的和正常兔肺泡巨噬细胞中超氧阴离子产生及超氧化物歧化酶水平的影响。
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The adrenochrome pathway. A potential catabolic route for adrenaline metabolism in inflammatory disease.肾上腺色素途径。炎症性疾病中肾上腺素代谢的一种潜在分解代谢途径。
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本文引用的文献

1
Lysozyme content of alveolar and peritoneal macrophages from the rabbit.兔肺泡巨噬细胞和腹腔巨噬细胞的溶菌酶含量
J Immunol. 1961 Feb;86:133-6.
2
Factors influencing myeloperoxidase and catalase activities in polymorphonuclear leukocytes.影响多形核白细胞中髓过氧化物酶和过氧化氢酶活性的因素。
Biochim Biophys Acta. 1967 Oct 9;148(1):243-50. doi: 10.1016/0304-4165(67)90299-1.
3
Studies of the metabolic activity of leukocytes from patients with a genetic abnormality of phagocytic function.对具有吞噬功能遗传异常患者的白细胞代谢活性的研究。
J Clin Invest. 1967 Sep;46(9):1422-32. doi: 10.1172/JCI105634.
4
The metabolism of leukocytes.白细胞的新陈代谢。
Semin Hematol. 1968 Apr;5(2):156-65.
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A modified procedure for the determination of leukocyte alkaline phosphatase.一种改良的白细胞碱性磷酸酶测定方法。
Biochem Med. 1970 Aug;4(1):61-8. doi: 10.1016/0006-2944(70)90103-1.
6
Role of the phagocyte in host-parasite interactions. XXII. H2O2-dependent decarbosylation and deamination by myeloperoxidase and its relationship to antimicrobial activity.吞噬细胞在宿主-寄生虫相互作用中的作用。XXII. 髓过氧化物酶介导的H2O2依赖性脱羧和脱氨作用及其与抗菌活性的关系。
J Reticuloendothel Soc. 1970 Jun;7(6):754-61.
7
Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein).超氧化物歧化酶。红细胞铜蛋白（血铜蛋白）的酶功能。
J Biol Chem. 1969 Nov 25;244(22):6049-55.
8
An enzyme-based theory of obligate anaerobiosis: the physiological function of superoxide dismutase.基于酶的专性厌氧菌理论：超氧化物歧化酶的生理功能。
Proc Natl Acad Sci U S A. 1971 May;68(5):1024-7. doi: 10.1073/pnas.68.5.1024.
9
Iodination of bacteria: a bactericidal mechanism.细菌的碘化作用：一种杀菌机制。
J Exp Med. 1967 Dec 1;126(6):1063-78. doi: 10.1084/jem.126.6.1063.
10
Superoxide dismutase. Organelle specificity.超氧化物歧化酶。细胞器特异性。
J Biol Chem. 1973 May 25;248(10):3582-92.

白细胞中的超氧化物歧化酶活性。

Superoxide dismutase activity in leukocytes.

作者信息

DeChatelet L R, McCall C E, McPhail L C, Johnston R B

出版信息

J Clin Invest. 1974 Apr;53(4):1197-201. doi: 10.1172/JCI107659.

DOI:10.1172/JCI107659
PMID:4815084
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC333107/
Abstract

Superoxide dismutase activity has been identified in both human neutrophils and rabbit alveolar macrophages by two distinct assay procedures. The enzyme is insensitive to both cyanide and azide and is present in the cytosol of the cell. The identification of this enzyme in phagocytic cells is compatible with the theory that superoxide anion might be involved in the bactericidal activity of the cell. It is proposed that the enzyme functions to protect the cell against superoxide generated during the phagocytic process.

摘要

通过两种不同的测定方法，已在人类中性粒细胞和兔肺泡巨噬细胞中鉴定出超氧化物歧化酶活性。该酶对氰化物和叠氮化物均不敏感，且存在于细胞的胞质溶胶中。在吞噬细胞中鉴定出这种酶与超氧阴离子可能参与细胞杀菌活性的理论相符。有人提出，该酶的作用是保护细胞免受吞噬过程中产生的超氧化物的伤害。