白细胞中的超氧化物歧化酶活性。
Superoxide dismutase activity in leukocytes.
作者信息
DeChatelet L R, McCall C E, McPhail L C, Johnston R B
出版信息
J Clin Invest. 1974 Apr;53(4):1197-201. doi: 10.1172/JCI107659.
Abstract
Superoxide dismutase activity has been identified in both human neutrophils and rabbit alveolar macrophages by two distinct assay procedures. The enzyme is insensitive to both cyanide and azide and is present in the cytosol of the cell. The identification of this enzyme in phagocytic cells is compatible with the theory that superoxide anion might be involved in the bactericidal activity of the cell. It is proposed that the enzyme functions to protect the cell against superoxide generated during the phagocytic process.
摘要
通过两种不同的测定方法，已在人类中性粒细胞和兔肺泡巨噬细胞中鉴定出超氧化物歧化酶活性。该酶对氰化物和叠氮化物均不敏感，且存在于细胞的胞质溶胶中。在吞噬细胞中鉴定出这种酶与超氧阴离子可能参与细胞杀菌活性的理论相符。有人提出，该酶的作用是保护细胞免受吞噬过程中产生的超氧化物的伤害。
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