从减毒的贝氏柯克斯体M-44菌株生产高效疫苗。
Production of a potent vaccine from the attenuated M-44 strain of Coxiella burneti.
作者信息
Robinson D M, Hasty S E
出版信息
Appl Microbiol. 1974 Apr;27(4):777-83. doi: 10.1128/am.27.4.777-783.1974.
Abstract
The attenuated M-44 strain of Coxiella burneti was heated to free it of adventitious agents that may have been present. Parallel titrations of the strain before and after heating indicated that the virulence for guinea pigs was markedly decreased. Guinea pigs immunized with the strain derived after heat treatment were protected from the effects of challenge with C. burneti in either phase I or II.
摘要
将减毒的伯氏考克斯氏体M - 44菌株加热，以去除可能存在的外来因子。加热前后对该菌株进行平行滴定，结果表明其对豚鼠的毒力显著降低。用热处理后获得的菌株免疫的豚鼠，在第一阶段或第二阶段均受到保护，免受伯氏考克斯氏体攻击的影响。
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