Kishimoto R A, Johnson J W, Kenyon R H, Ascher M S, Larson E W, Pedersen C E
Infect Immun. 1978 Jan;19(1):194-8. doi: 10.1128/iai.19.1.194-198.1978.
The ability of a killed phase I Coxiella burnetii vaccine to induce cell-mediated immune responses in guinea pigs was studied. Cell-mediated immune responses were assessed by the inhibition of macrophage migration and lymphocyte transformation assays. The macrophage migration response occurred rapidly and was detected at high levels, but was relatively short-lived. In contrast, the lymphocyte transformation response developed more slowly, and persisted for a longer period. The vaccine, given in a single dose or in two doses 1 week apart, protected guinea pigs from a subsequent virulent challenge.
研究了灭活的Ⅰ期伯纳特柯克斯体疫苗在豚鼠中诱导细胞介导免疫反应的能力。通过巨噬细胞迁移抑制试验和淋巴细胞转化试验评估细胞介导的免疫反应。巨噬细胞迁移反应迅速发生且水平较高，但持续时间相对较短。相比之下，淋巴细胞转化反应发展较慢，但持续时间更长。单剂量或间隔1周分两剂接种的疫苗可保护豚鼠免受随后的强毒株攻击。
