Ansell J D, McDougall C M, Micklem H S, Inchley C J
Immunology. 1980 Aug;40(4):687-94.
Antigen-dependent localization of 51Cr-labelled lymphocytes, and the subsequent uptake of IUdR into lymphoid organs has been studied as a function of age. Measures of cell localization indicated that while old age can alter the patterns of entry of lymphocytes into lymph nodes and spleen, these changes are variable and probably not sufficient alone to explain decreased primary antibody responses in old animals. Proliferation of cells, however, was consistently affected in both organs and this phenomenon is discussed in terms of abnormal T-cell function.
研究了51Cr标记淋巴细胞的抗原依赖性定位以及随后碘脱氧尿苷（IUdR）在淋巴器官中的摄取与年龄的关系。细胞定位测量表明，虽然老年会改变淋巴细胞进入淋巴结和脾脏的模式，但这些变化是可变的，可能不足以单独解释老年动物初次抗体反应下降的原因。然而，两个器官中的细胞增殖均持续受到影响，并且根据T细胞功能异常对这一现象进行了讨论。
