Griffiths M M, Smith C B, Pepper B J
Arthritis Rheum. 1978 Jan-Feb;21(1):97-105. doi: 10.1002/art.1780210116.
Fibroblastic cells derived from rheumatoid (RA) and nonrheumatoid (N-RA) synovial tissue (synovial cells) were used as targets in assays of antibody-dependent cell-mediated cytotoxicity (ADCC). Synovial cells that had been pretreated with human alloantisera were rapidly lysed by normal human blood mononuclear cells. RA and N-RA synovial cells were equally susceptible to ADCC under these assay conditions. Antibody to autologous synovial cells was not detected in sera from 10 patients with RA by this method of assay.
源自类风湿性关节炎（RA）和非类风湿性关节炎（N - RA）滑膜组织的成纤维细胞（滑膜细胞）被用作抗体依赖性细胞介导的细胞毒性（ADCC）检测的靶标。用人类同种抗血清预处理过的滑膜细胞会被正常人血液单核细胞迅速裂解。在这些检测条件下，RA和N - RA滑膜细胞对ADCC的敏感性相同。通过这种检测方法，在10例RA患者的血清中未检测到针对自体滑膜细胞的抗体。
