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1
Radioautographic studies of plaque-forming cells. I. Antigen-stimulated proliferation of plaque-forming cells.噬斑形成细胞的放射自显影研究。I. 抗原刺激下噬斑形成细胞的增殖
J Exp Med. 1968 Aug 1;128(2):235-57. doi: 10.1084/jem.128.2.235.
2
Cell populations and cell proliferation in the in vitro response of normal mouse spleen to heterologous erythrocytes. Analysis by the hot pulse technique.正常小鼠脾脏对异种红细胞体外反应中的细胞群体与细胞增殖。热脉冲技术分析
J Exp Med. 1967 Sep 1;126(3):443-54. doi: 10.1084/jem.126.3.443.
3
The life cycle of antibody-forming cells. I. The generation time of 19S hemolytic plaque-forming cells during the primary and secondary responses.抗体形成细胞的生命周期。I. 初次和二次应答期间19S溶血空斑形成细胞的生成时间。
J Exp Med. 1968 Nov 1;128(5):895-925. doi: 10.1084/jem.128.5.895.
4
Antibody production in vitro. I. Single cell studies of the secondary response to sheep erythrocytes.体外抗体产生。I. 对绵羊红细胞二次反应的单细胞研究。
J Exp Med. 1968 Apr 1;127(4):661-74. doi: 10.1084/jem.127.4.661.
5
Immunoglobulin classes of antibody-forming cells in mice. IV. The incorporation of tritiated thymidine into IgM and gamma 1 plaque-forming cells during the primary immune response.小鼠中抗体形成细胞的免疫球蛋白类别。IV. 初次免疫应答期间氚标记胸腺嘧啶核苷掺入IgM和γ1斑块形成细胞的情况。
J Immunol. 1970 Jul;105(1):154-61.
6
Autoradiographic studies on the proliferation of antibody-producing cells in vitro.体外抗体产生细胞增殖的放射自显影研究。
J Exp Med. 1974 Mar 1;139(3):754-60. doi: 10.1084/jem.139.3.754.
7
The rate of division of antibody-forming cells during the early primary immune response.初次免疫应答早期抗体形成细胞的分裂速率。
J Exp Med. 1968 May 1;127(5):983-1002. doi: 10.1084/jem.127.5.983.
8
The effects of antigens and of phytohemagglutinin on rabbit spleen cell suspensions.抗原和植物血凝素对兔脾细胞悬液的作用。
J Exp Med. 1966 Oct 1;124(4):621-34. doi: 10.1084/jem.124.4.621.
9
Relationship of germinal centers in lymphoid tissue to immunological memory. I. Evidence for the formation of small lymphocytes upon transfer of primed splenic white pulp to syngeneic mice.淋巴组织中生发中心与免疫记忆的关系。I. 经致敏脾白髓转移至同基因小鼠后小淋巴细胞形成的证据。
J Exp Med. 1968 Jul 1;128(1):153-69. doi: 10.1084/jem.128.1.153.
10
Induction of antigenic competition with thymus-dependent antigens: effect on DNA synthesis in spleen cells.胸腺依赖性抗原诱导抗原竞争：对脾细胞DNA合成的影响。
J Immunol. 1971 Jun;106(6):1566-71.

引用本文的文献

1
Cell interactions in the primary immune response in vitro: a requirement for specific cell clusters.体外初次免疫应答中的细胞相互作用：特定细胞簇的需求。
J Exp Med. 1969 Feb 1;129(2):351-62. doi: 10.1084/jem.129.2.351.
2
Cellular events during the expression of immunologic memory.免疫记忆表达过程中的细胞事件。
Clin Exp Immunol. 1970 Oct;7(4):565-82.
3
The early antibody-forming response to Salmonella antigens. A study of morphology and kinetics in vivo and in vitro.对沙门氏菌抗原的早期抗体形成反应。体内和体外的形态学与动力学研究。
Immunology. 1970 Oct;19(4):651-67.
4
Studies on antibody-producing cells. II. Appearance of 3 H-thymidine-labeled rosette-forming cells.抗体产生细胞的研究。II. 3H-胸腺嘧啶核苷标记的玫瑰花结形成细胞的出现
J Exp Med. 1971 Feb 1;133(2):305-20. doi: 10.1084/jem.133.2.305.
5
Studies on antibody-producing cells. 3. Identification of young plaque-forming cells by thymidine- 3 H labeling.抗体产生细胞的研究。3. 用氚标记胸腺嘧啶核苷鉴定幼龄空斑形成细胞。
J Exp Med. 1971 Nov 1;134(5):1155-69. doi: 10.1084/jem.134.5.1155.
6
Immune responses in vitro. 3. Development of primary gamma-M, gamma-G, and gamma-A plaque-forming cell responses in mouse spleen cell cultures stimulated with heterologous erythrocytes.体外免疫反应。3. 用异种红细胞刺激小鼠脾细胞培养物中主要γ-M、γ-G和γ-A斑块形成细胞反应的发展。
J Exp Med. 1971 Aug 1;134(2):395-416. doi: 10.1084/jem.134.2.395.
7
Cyclic kinetics and mathematical expression of the primary immune response of soluble antigen. 3. Cellular activity of antigen.可溶性抗原初次免疫应答的循环动力学及数学表达。3. 抗原的细胞活性。
Folia Microbiol (Praha). 1973;18(4):308-14. doi: 10.1007/BF02868048.
8
Cyclic kinetics and mathematical expression of the primary immune response to soluble antigen. II. The mathematical expression of some elements of the primary immune response.可溶性抗原初次免疫应答的循环动力学及数学表达式。II. 初次免疫应答某些要素的数学表达式。
Folia Microbiol (Praha). 1973;18(3):237-41. doi: 10.1007/BF02872862.
9
Studies on antibody-producing cells. IV. Ultrastructue of plaque-forming cells of rabbit lymph.抗体产生细胞的研究。IV. 兔淋巴结中噬斑形成细胞的超微结构
J Exp Med. 1972 Mar 1;135(3):491-502. doi: 10.1084/jem.135.3.491.
10
Characterization of the antibody response to type 3 pneumococcal polysaccharide at the cellular level. II. Studies on the relative rate of antibody synthesis and release by antibody-producing cells.在细胞水平对3型肺炎球菌多糖抗体反应的特征描述。II. 对抗体产生细胞抗体合成和释放相对速率的研究。
Immunology. 1971 Apr;20(4):481-92.

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CELLULAR PROLIFERATION IN THE MOUSE AS REVEALED BY AUTORADIOGRAPHY WITH TRITIATED THYMIDINE.用氚标记胸腺嘧啶放射自显影术显示的小鼠细胞增殖
Proc Natl Acad Sci U S A. 1958 May;44(5):476-83. doi: 10.1073/pnas.44.5.476.
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Autoradiographic studies on the immune response.I. The kinetics of plasma cell proliferation.免疫反应的放射自显影研究。I. 浆细胞增殖的动力学
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EFFECT OF OVARIAN HORMONES ON DURATION OF DNA SYNTHESIS IN CELLS OF THE C3H MOUSE MAMMARY GLAND.卵巢激素对C3H小鼠乳腺细胞DNA合成持续时间的影响。
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DNA SYNTHESIS IN ALVEOLAR CELLS OF THE MAMMARY GLAND: ACCELERATION BY OVARIAN HORMONES.
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AN IN VITRO SYSTEM FOR THE STUDY OF THE MECHANISM OF ANTIGENIC STIMULATION IN THE SECONDARY RESPONSE.用于研究二次反应中抗原刺激机制的体外系统。
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Plaque formation in agar by single antibody-producing cells.单个产生抗体的细胞在琼脂中形成菌斑。
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The leucocyte as a possible exception to the theory of deoxyribonucleic acid constancy.白细胞可能是脱氧核糖核酸恒定性理论的一个例外。
J Pathol Bacteriol. 1963 Apr;85:311-26. doi: 10.1002/path.1700850208.
8
The deoxyribonucleic acid content of the leucocytes in human blood, bone-marrow and lymph-glands.人类血液、骨髓和淋巴结中白细胞的脱氧核糖核酸含量。
J Pathol Bacteriol. 1961 Oct;82:483-501. doi: 10.1002/path.1700820225.
9
Dynamics of hemopoietic proliferation in man and mice studied by H3-thymidine incorporation into DNA.通过将H3-胸腺嘧啶核苷掺入DNA对人和小鼠造血增殖动力学的研究。
Ann N Y Acad Sci. 1959 Jun 25;77:803-20. doi: 10.1111/j.1749-6632.1959.tb36943.x.
10
The use of tritiated thymidine in the study of DNS synthesis and cell turnover in hemopoietic tissues.氚标记胸腺嘧啶核苷在造血组织中DNA合成及细胞更新研究中的应用。
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噬斑形成细胞的放射自显影研究。I. 抗原刺激下噬斑形成细胞的增殖

Radioautographic studies of plaque-forming cells. I. Antigen-stimulated proliferation of plaque-forming cells.

作者信息

Koros A M, Mazur J M, Mowery M J

出版信息

J Exp Med. 1968 Aug 1;128(2):235-57. doi: 10.1084/jem.128.2.235.

DOI:10.1084/jem.128.2.235
PMID:4873020
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2138519/
Abstract

A method has been described for obtaining radioautographs of plaque-forming cells. The method permits radioautographic analyses of small numbers of plaque-forming cells amidst large populations of non-plaque-forming cells. Spleen cells that were pulse-labeled with tritiated thymidine could be categorized readily as labeled or not labeled. Using this method it was found that (a) at least 55% of plaque-forming cells which appear 3 days after a maximal stimulus of 4 x 10(8) sheep red cells are still capable of DNA synthesis, and must have arisen by cell proliferation; (b) the rate of proliferation of plaque-forming cells is proportional to the log of the dose of antigen; (c) the S period of plaque-forming cells is at least 2 hr, appears to be constant, and is not influenced by antigen dose. The results suggest that antigen stimulates proliferation of plaque-forming cells by hastening their transit through the G(1) phase of the generative cycle.

摘要

已描述了一种获得噬斑形成细胞放射自显影照片的方法。该方法允许在大量非噬斑形成细胞中对少量噬斑形成细胞进行放射自显影分析。用氚标记的胸腺嘧啶核苷脉冲标记的脾细胞可很容易地分类为标记或未标记。使用该方法发现：（a）在4×10⁸个绵羊红细胞最大刺激后3天出现的噬斑形成细胞中，至少55%仍能够进行DNA合成，且必定是通过细胞增殖产生的；（b）噬斑形成细胞的增殖速率与抗原剂量的对数成正比；（c）噬斑形成细胞的S期至少为2小时，似乎是恒定的，且不受抗原剂量的影响。结果表明，抗原通过加速噬斑形成细胞在生成周期的G₁期的过渡来刺激其增殖。