Stewart F S, McLoughlin M
Immunology. 1968 Jul;15(1):13-22.
Substances that can combine with and prevent red cell sensitization by various streptococcal and Gram-negative bacillary antigens are demonstrable in normal human serum. The inhibitors combining with two serologically distinct streptococcal sensitizing antigens—Hickey and 8029—were found to be heat stable, not precipitable by trichloracetic acid, non-antigenic in the rabbit, separable on Sephadex G-200 and by starch block electrophoresis from both serum albumin and serum γ-globulin and, unlike influenza virus haemagglutination inhibitor, not inactivated by trypsin, periodate or a bacterial () receptor-destroying enzyme. The inhibitors were specifically absorbable by the homologous bacterial cells but the antigen groups determining this specificity were distinguishable from those that combined with homologous antibody. Inhibitors combining with the red cell sensitizing antigens of the Gram-negative bacteria examined appeared to have similar properties but were not found to be absorbable by homologous bacterial cells.
在正常人血清中可证明存在能与各种链球菌和革兰氏阴性杆菌抗原结合并防止红细胞致敏的物质。已发现与两种血清学上不同的链球菌致敏抗原——希基（Hickey）和8029——结合的抑制剂对热稳定，不被三氯乙酸沉淀，在兔体内无抗原性，可通过葡聚糖凝胶G - 200以及淀粉区带电泳与血清白蛋白和血清γ球蛋白分离，并且与流感病毒血凝抑制剂不同，不被胰蛋白酶、高碘酸盐或细菌（）受体破坏酶灭活。这些抑制剂可被同源细菌细胞特异性吸收，但决定这种特异性的抗原基团与那些与同源抗体结合的抗原基团不同。与所检测的革兰氏阴性菌的红细胞致敏抗原结合的抑制剂似乎具有相似的特性，但未发现可被同源细菌细胞吸收。
