Barth W F, Gordon J K, Willerson J T
Science. 1968 Nov 8;162(3854):694-5. doi: 10.1126/science.162.3854.694.
Amyloidosis was produced in mice by repeated subcutaneous injections of 0.5-or 0.005-milligram amounts of Escherichia coli endotoxin. Of the two strains of mice examined, amyloidosis was induced more readily in one than in the other. The ability of endotoxin to induce amyloidosis lends support to the view that stimulation of reticuloendothelial cells leads to amyloid formation.
通过反复皮下注射0.5毫克或0.005毫克的大肠杆菌内毒素在小鼠中诱发淀粉样变性。在所检查的两种小鼠品系中，其中一种比另一种更容易诱发淀粉样变性。内毒素诱发淀粉样变性的能力支持了网状内皮细胞的刺激会导致淀粉样蛋白形成的观点。
