Collins W E, Warren M, Skinner J C, Fredericks H J
Bull World Health Organ. 1968;39(3):451-63.
The fluorescent antibody (FA) technique was used to detect the presence of malarial antibody in populations living in 3 different ecological areas of Malaysia. Serum samples were tested using Plasmodium falciparum, P. vivax, P. malariae and P. fieldi antigens. An area of hyperendemic malaria had a good correlation between the antibody responses and active parasitaemias. The percentage and intensity of responses increased with the age of the individuals. In an area of hypoendemic malaria, each of 17 sites had ecological conditions which would favour or discourage the transmission of malaria. The reasons for high FA responses in some villages and low responses in others were readily apparent. The effect of even limited control programmes on the malarial ecology could be measured by an examination of the antibody responses. An aboriginal population receiving suppressive drugs had FA responses indicating both past experience and the effect of the drug programme.
荧光抗体（FA）技术用于检测生活在马来西亚3个不同生态区域人群中疟原虫抗体的存在情况。血清样本采用恶性疟原虫、间日疟原虫、三日疟原虫和菲氏疟原虫抗原进行检测。疟疾高度流行地区的抗体反应与现症寄生虫血症之间具有良好的相关性。反应的百分比和强度随个体年龄的增长而增加。在疟疾低度流行地区，17个地点中的每一个都有有利于或不利于疟疾传播的生态条件。一些村庄FA反应高而另一些村庄反应低的原因显而易见。通过检查抗体反应可以衡量即使是有限的控制项目对疟疾生态的影响。接受抑制性药物治疗的原住民群体的FA反应表明了既往感染情况以及药物治疗项目的效果。
