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提高大肠杆菌K-12紫外线照射后存活率的R因子。

R factors improving survival of Escherichia coli K-12 after ultraviolet irradiation.

作者信息

Marsh E B, Smith D H

出版信息

J Bacteriol. 1969 Oct;100(1):128-39. doi: 10.1128/jb.100.1.128-139.1969.

Abstract

Two R factors which have the capacity to improve survival of some strains of Escherichia coli K-12 by approximately 60% after ultraviolet light have been identified and characterized. Both are fi(-), but neither produce colicins. The ability to enhance survival can be separated from all other identified R-factor functions. Improved survival does not result from improved excisional capacity, but does require an intact host capacity for genetic recombination. No effects on host cell growth or postirradiation lag were observed. A proposed mechanism of action is described.

摘要

已鉴定并表征了两种R因子,它们能够在紫外线照射后将某些大肠杆菌K-12菌株的存活率提高约60%。这两种R因子均为fi(-),但均不产生大肠杆菌素。提高存活率的能力可以与所有其他已鉴定的R因子功能分离。存活率的提高并非源于切除能力的改善,但确实需要宿主具备完整的基因重组能力。未观察到对宿主细胞生长或照射后延迟的影响。本文描述了一种推测的作用机制。

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引用本文的文献

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Colicins.大肠杆菌素
Annu Rev Microbiol. 1957;11:7-22. doi: 10.1146/annurev.mi.11.100157.000255.
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R factors mediate resistance to mercury, nickel, and cobalt.R因子介导对汞、镍和钴的抗性。
Science. 1967 May 26;156(3778):1114-6. doi: 10.1126/science.156.3778.1114.
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Mode of action of novobiocin in Escherichia coli.新生霉素在大肠杆菌中的作用模式。
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