在微生物群落确定的小鼠中传染性耐药性的转移
Transfer of infectious drug resistance in microbially defined mice.
作者信息
Reed N D, Sieckmann D G, Georgi C E
出版信息
J Bacteriol. 1969 Oct;100(1):22-6. doi: 10.1128/jb.100.1.22-26.1969.
Abstract
Germ-free mice were intentionally associated with drug-resistant donor strains of Escherichia coli known to carry R factors and with drug-sensitive recipient strains. In vivo transfer of R factors was observed in all experiments, involving five different donor-recipient combinations. The number of converted recipients varied, depending upon the donor-recipient combination, but in all cases it was restricted by limiting numbers of either recipient or donor strains in the digestive tract of the microbially defined mice. Converted recipients were detected in fecal material as early as 5.5 hr after mice were associated with donor and recipient bacteria. Donors, recipients, and converted recipients were detectable in the stomach, small intestine, cecum, and large intestine of the microbially defined mice and their suckling young.
摘要
无菌小鼠被有意地与已知携带R因子的耐药性大肠杆菌供体菌株以及药物敏感的受体菌株建立联系。在所有实验中均观察到了R因子的体内转移，涉及五种不同的供体 - 受体组合。转化受体的数量因供体 - 受体组合而异，但在所有情况下，它都受到无菌小鼠消化道中受体或供体菌株数量有限的限制。早在小鼠与供体和受体细菌建立联系后5.5小时，就在粪便中检测到了转化受体。在无菌小鼠及其哺乳幼崽的胃、小肠、盲肠和大肠中都可检测到供体、受体和转化受体。
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