Bodel P
Yale J Biol Med. 1974;47(2):101-12.
The mechanism of fever in patients with Hodgkin's disease was investigated by examining endogenous pyrogen production by blood, spleen, and lymph node cells incubated in vitro. Blood leucocytes from febrile or afebrile patients with Hodgkin's disease did not produce pyrogen spontaneously. Spleen cells, however, frequently released pyrogen during initial incubations, unlike spleen cells from patients with non-malignant diseases. Pyrogen production occurred from spleens without observed pathologic infiltrates of Hodgkin's disease. Lymph nodes involved with Hodgkin's disease produced pyrogen more frequently than did nodes involved with other diseases. Pyrogen production by tissue cells was prolonged, required protein synthesis, and in some cases was due to mononuclear cells; it did not correlate with fever in the patient. These studies demonstrate spontaneous production of endogenous pyrogen in vitro by lymphoid tissue cells from patients with Hodgkin's disease.
通过检测体外培养的血液、脾脏和淋巴结细胞产生内源性致热原的情况，对霍奇金病患者发热的机制进行了研究。发热或不发热的霍奇金病患者的血液白细胞不会自发产生致热原。然而，与非恶性疾病患者的脾细胞不同，霍奇金病患者的脾细胞在初次培养时经常释放致热原。没有观察到霍奇金病病理浸润的脾脏也会产生致热原。与其他疾病累及的淋巴结相比，霍奇金病累及的淋巴结更频繁地产生致热原。组织细胞产生致热原的过程延长，需要蛋白质合成，在某些情况下是由单核细胞引起的；它与患者的发热无关。这些研究表明，霍奇金病患者的淋巴组织细胞在体外可自发产生内源性致热原。
