Otte M, Forell M M
Klin Wochenschr. 1979 Aug 1;57(15):789-92. doi: 10.1007/BF01478037.
The purpose of the study was to examine the secretory response of the exocrine pancreas in man to various doses of the synthesised decapeptide Caerulein (Takus), 5, 10 and 20 ng/kg Caerulein injected intravenously during an infusion of 0,5 CU/kg/h Secretin (GIH) produced a linear increase of enzyme secretion (amylase, lipase, trypsin and chymotrypsin) and also an increase in the water and bicarbonate secretion of the pancreas which is induced by Secretin. The injection of 40 ng/kg Caerulein led to no further increase of the ecbolic function. The intravenous injection of 1 Ivy dog unit (IDU/kg and 20 and 40 ng/kg Caerulein have an identical effect on the exocrine pancreas, there were no statistic differences.
该研究的目的是检查人体外分泌胰腺对不同剂量合成十肽蛙皮素（Takus）的分泌反应，在以0.5 CU/kg/h的速度静脉输注促胰液素（胃肠抑制肽）期间，静脉注射5、10和20 ng/kg的蛙皮素会使酶分泌（淀粉酶、脂肪酶、胰蛋白酶和糜蛋白酶）呈线性增加，同时也会使促胰液素诱导的胰腺水和碳酸氢盐分泌增加。注射40 ng/kg蛙皮素不会导致催产功能进一步增加。静脉注射1个常春藤犬单位（IDU/kg）以及20和40 ng/kg蛙皮素对外分泌胰腺有相同的作用，不存在统计学差异。
