Papatestas A E, Bramis J, Aufses A H
J Surg Oncol. 1979;12(2):155-63. doi: 10.1002/jso.2930120209.
Serum immunoglobulins were determined in 120 women with breast cancer. A strong association between age at tumor diagnosis and serum IgA levels was noted. Relative hypoglobulinemia of IgA was associated with appearance of tumors early in life, and was more frequent among women with family history of breast cancer and among those with poor prognosis. A strong association between levels of serum IgG and parity was noted. Parous women and/or those who had good prognosis had higher levels of serum IgG, compared to nulliparous women and those with poor prognosis. The observations indicate that serum immunoglobulins may be useful in the identification of women who have a high breast cancer risk and poor prognosis.
对120名乳腺癌女性患者进行了血清免疫球蛋白检测。结果发现肿瘤诊断时的年龄与血清IgA水平之间存在密切关联。IgA相对球蛋白缺乏症与早年出现肿瘤有关，在有乳腺癌家族史的女性以及预后较差的女性中更为常见。还发现血清IgG水平与产次之间存在密切关联。与未生育女性和预后较差的女性相比，经产女性和/或预后良好的女性血清IgG水平更高。这些观察结果表明，血清免疫球蛋白可能有助于识别乳腺癌风险高且预后差的女性。
