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体内X射线诱导的DNA链断裂快速修复所需的DNA聚合酶。

DNA polymerase required for rapid repair of x-ray--induced DNA strand breaks in vivo.

作者信息

Town C D, Smith K C, Kaplan H S

出版信息

Science. 1971 May 21;172(3985):851-4. doi: 10.1126/science.172.3985.851.

DOI:10.1126/science.172.3985.851
PMID:4929534
Abstract

A much higher yield of DNA single-strand breaks was obtained in the DNA polymerase-deficient mutant Escherichia coli K-12 pol A1 after a given dose of x-rays than had been found before in Escherichia coli. The increased yield of single-strand breaks was due to the absence of a rapid repair system, which had not been described in Escherichia coli K-12. This absence probably accounts for the x-ray sensitivity of the pol A1 mutant. The rapid repair system can be reversibly inhibited in pol+ cells.

摘要

在给予一定剂量的X射线后，DNA聚合酶缺陷型突变体大肠杆菌K-12 pol A1中获得的DNA单链断裂产量比之前在大肠杆菌中发现的要高得多。单链断裂产量的增加是由于缺乏一种快速修复系统，这种系统在大肠杆菌K-12中尚未被描述。这种缺失可能是pol A1突变体对X射线敏感的原因。快速修复系统在pol+细胞中可被可逆性抑制。

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