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1
Anaerobic incubation enhances the colony formation of a polA recB strain of Escherichia coli K-12.厌氧培养可增强大肠杆菌K-12的polA recB菌株的菌落形成。
J Bacteriol. 1982 Oct;152(1):208-14. doi: 10.1128/jb.152.1.208-214.1982.
2
Restoration of viability to an Escherichia coli mutant deficient in the 5'----3' exonuclease of DNA polymerase I.使DNA聚合酶I的5'→3'核酸外切酶缺陷型大肠杆菌突变体恢复活力。
J Bacteriol. 1984 Nov;160(2):706-10. doi: 10.1128/jb.160.2.706-710.1984.
3
Role of DNA polymerase I in postreplication repair: a reexamination with Escherichia coli delta polA.DNA聚合酶I在复制后修复中的作用：用大肠杆菌δpolA进行的重新研究
J Bacteriol. 1987 Oct;169(10):4559-64. doi: 10.1128/jb.169.10.4559-4564.1987.
4
Excision repair characteristics of recB - res - and uvrC - strains of Escherichia coli.大肠杆菌recB - res - 和uvrC - 菌株的切除修复特性
J Bacteriol. 1972 Dec;112(3):1237-46. doi: 10.1128/jb.112.3.1237-1246.1972.
5
Separate branches of the uvr gene-dependent excision repair process in ultraviolet-irradiated Escherichia coli K-12 cells; their dependence upon growth medium and the polA, recA, recB, and exrA genes.紫外线照射的大肠杆菌K-12细胞中uvr基因依赖性切除修复过程的不同分支；它们对生长培养基以及polA、recA、recB和exrA基因的依赖性。
J Bacteriol. 1974 Feb;117(2):717-25. doi: 10.1128/jb.117.2.717-725.1974.
6
Evidence that the gene uvrB is indispensable for a polymerase I deficient strain of Escherichia coli K-12.基因uvrB对于大肠杆菌K - 12的聚合酶I缺陷菌株不可或缺的证据。
Mol Gen Genet. 1976 Sep 23;147(3):243-50. doi: 10.1007/BF00582875.
7
[Effect of neocarzinostatin on E. coli mutants deficient in DNA repair].[新制癌菌素对DNA修复缺陷型大肠杆菌突变体的作用]
Z Naturforsch C J Biosci. 1989 Sep-Oct;44(9-10):791-6.
8
X-ray sensitivity and repair capacity of a polA1 exrA strain of Escherichia coli K-12.大肠杆菌K-12的polA1 exrA菌株的X射线敏感性和修复能力
J Bacteriol. 1973 Apr;114(1):121-7. doi: 10.1128/jb.114.1.121-127.1973.
9
Evidence for the control by exrA and polA genes of two branches of the uvr gene-dependent excision repair pathway in Escherichia coli K-12.关于大肠杆菌K-12中uvr基因依赖性切除修复途径的两个分支受exrA和polA基因调控的证据。
J Bacteriol. 1973 Oct;116(1):175-82. doi: 10.1128/jb.116.1.175-182.1973.
10
A minor pathway of postreplication repair in Escherichia coli is independent of the recB, recC and recF genes.大肠杆菌中复制后修复的一条次要途径独立于recB、recC和recF基因。
Mutat Res. 1985 Sep;146(2):169-76. doi: 10.1016/0167-8817(85)90007-0.

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How Microbes Defend Themselves From Incoming Hydrogen Peroxide.微生物如何抵御入侵的过氧化氢。
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How Microbes Evolved to Tolerate Oxygen.微生物如何进化以耐受氧气。
Trends Microbiol. 2021 May;29(5):428-440. doi: 10.1016/j.tim.2020.10.001. Epub 2020 Oct 24.
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Where in the world do bacteria experience oxidative stress?细菌在世界的哪个地方会经历氧化应激？
Environ Microbiol. 2019 Feb;21(2):521-530. doi: 10.1111/1462-2920.14445. Epub 2018 Nov 19.
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Replication Fork Breakage and Restart in Escherichia coli.大肠杆菌中复制叉的断裂与重连。
Microbiol Mol Biol Rev. 2018 Jun 13;82(3). doi: 10.1128/MMBR.00013-18. Print 2018 Sep.
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Improved measurements of scant hydrogen peroxide enable experiments that define its threshold of toxicity for Escherichia coli.提高痕量过氧化氢的测量能力使实验能够确定其对大肠杆菌毒性的阈值。
Free Radic Biol Med. 2018 May 20;120:217-227. doi: 10.1016/j.freeradbiomed.2018.03.025. Epub 2018 Mar 14.
6
Cellular defenses against superoxide and hydrogen peroxide.细胞对超氧化物和过氧化氢的防御机制。
Annu Rev Biochem. 2008;77:755-76. doi: 10.1146/annurev.biochem.77.061606.161055.
7
Historical overview: searching for replication help in all of the rec places.历史概述：在所有推荐的地方寻找复制帮助。
Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8173-80. doi: 10.1073/pnas.131004998.
8
Recombinational repair of DNA damage in Escherichia coli and bacteriophage lambda.大肠杆菌和噬菌体λ中DNA损伤的重组修复
Microbiol Mol Biol Rev. 1999 Dec;63(4):751-813, table of contents. doi: 10.1128/MMBR.63.4.751-813.1999.
9
Bimodal pattern of killing of DNA-repair-defective or anoxically grown Escherichia coli by hydrogen peroxide.过氧化氢对DNA修复缺陷型或缺氧培养的大肠杆菌的双峰杀伤模式。
J Bacteriol. 1986 May;166(2):519-27. doi: 10.1128/jb.166.2.519-527.1986.
10
Spontaneous mutagenesis and oxidative damage to DNA in Salmonella typhimurium.鼠伤寒沙门氏菌中的自发诱变及DNA的氧化损伤
Proc Natl Acad Sci U S A. 1987 Dec;84(24):8917-21. doi: 10.1073/pnas.84.24.8917.

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Cytoplasmic membrane fraction that promotes septation in an Escherichia coli lon mutant.促进大肠杆菌lon突变体中细胞分裂的细胞质膜组分。
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The recA+ gene product is more important than catalase and superoxide dismutase in protecting Escherichia coli against hydrogen peroxide toxicity.在保护大肠杆菌免受过氧化氢毒性影响方面，recA+基因产物比过氧化氢酶和超氧化物歧化酶更重要。
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Repair of radiation-induced damage to the cell division mechanism of Escherichia coli.大肠杆菌细胞分裂机制辐射损伤的修复
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Slow joining of newly replicated DNA chains in DNA polymerase I-deficient Escherichia coli mutants.DNA聚合酶I缺陷型大肠杆菌突变体中新复制DNA链的缓慢连接。
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Repair of damage induced by ultraviolet light in DNA polymerase-defective Escherichia coli cells.DNA聚合酶缺陷型大肠杆菌细胞中紫外线诱导损伤的修复
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DNA polymerase required for rapid repair of x-ray--induced DNA strand breaks in vivo.体内X射线诱导的DNA链断裂快速修复所需的DNA聚合酶。
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Repair of radiation-induced damage in Escherichia coli. I. Effect of rec mutations on post-replication repair of damage due to ultraviolet radiation.大肠杆菌中辐射诱导损伤的修复。I. rec突变对紫外线辐射所致损伤的复制后修复的影响。
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Repair of radiation-induced damage in Escherichia coli. II. Effect of rec and uvr mutations on radiosensitivity, and repair of x-ray-induced single-strand breaks in deoxyribonucleic acid.大肠杆菌中辐射诱导损伤的修复。II. rec和uvr突变对辐射敏感性的影响，以及脱氧核糖核酸中X射线诱导的单链断裂的修复
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厌氧培养可增强大肠杆菌K-12的polA recB菌株的菌落形成。

Anaerobic incubation enhances the colony formation of a polA recB strain of Escherichia coli K-12.

作者信息

Morimyo M

出版信息

J Bacteriol. 1982 Oct;152(1):208-14. doi: 10.1128/jb.152.1.208-214.1982.

DOI:10.1128/jb.152.1.208-214.1982
PMID:6288657
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC221393/
Abstract

Escherichia coli strain E247 (polA1 recB21) has reduced colony formation (even at the permissive temperature of 30 degrees C) because of a poor suppressor mutation (sup-126). The colony formation was enhanced in the absence of oxygen about 3-fold at 30 degrees C and 10(6)-fold at 43 degrees C, suggesting that a polA recB strain was inviable due to oxygen toxicity. Colony formation was also increased by incubation in an agar medium containing the reducing agent thioglycolate and incubation in the presence of chloroform-killed Saccharomyces cerevisiae pet+ cells, but not pet cells. Since the E247 strain viability was inversely dependent on the oxygen pressure and since the strain was more sensitive to superoxide radical than either the polA or the recB mutant, it seems likely that the polA and recB genes play a role in repairing DNA damage during respiration.

摘要

大肠杆菌菌株E247（polA1 recB21）由于抑制突变不佳（sup-126），其菌落形成减少（即使在30摄氏度的允许温度下）。在无氧条件下，30摄氏度时菌落形成增强约3倍，43摄氏度时增强10^6倍，这表明polA recB菌株因氧毒性而无法存活。在含有还原剂巯基乙酸盐的琼脂培养基中培养以及在氯仿杀死的酿酒酵母pet+细胞（而非pet细胞）存在的情况下培养，菌落形成也会增加。由于E247菌株的活力与氧压力呈负相关，且该菌株比polA或recB突变体对超氧自由基更敏感，因此polA和recB基因似乎在呼吸过程中修复DNA损伤方面发挥作用。