Knight S, Ling N R, Sell S, Oxnard C E
Immunology. 1965 Dec;9(6):565-74.
The peripheral lymphocytes of monkeys, rabbits, guinea-pigs, hamsters, rats and mice were transformed in culture by phytohaemagglutinin and staphylococcal filtrate. The response was most marked with the peripheral lymphocytes of monkeys and rabbits and least marked with rat and mouse lymphocytes. The response occurred earlier with rabbit and guinea-pig than human lymphocytes. The short life span of rat and mouse lymphocytes adversely affected their response. The tritiated thymidine uptake of the stimulated lymphocytes of the various species was also limited by their rate of survival over the culture period. Attempts to obtain antigen-specific stimulation of peripheral rabbit and guinea-pig lymphocytes were unsuccessful.
猴、兔、豚鼠、仓鼠、大鼠和小鼠的外周淋巴细胞在培养中被植物血凝素和葡萄球菌滤液转化。猴子和兔子的外周淋巴细胞反应最为明显，而大鼠和小鼠淋巴细胞反应最不明显。兔和豚鼠的反应比人类淋巴细胞出现得更早。大鼠和小鼠淋巴细胞的短寿命对其反应产生了不利影响。在培养期间，不同物种受刺激淋巴细胞的氚化胸腺嘧啶核苷摄取也受到其存活速率的限制。试图对外周兔和豚鼠淋巴细胞进行抗原特异性刺激未获成功。
