淋巴细胞激活后钠依赖性氨基酸转运系统稳定性增强。
Enhanced stability of the Na+-dependent amino acid-transport system after lymphocyte activation.
作者信息
Borghetti A F, Kay J E
出版信息
Biochem J. 1979 Jul 15;182(1):237-9. doi: 10.1042/bj1820237.
Abstract
The Na+-dependent transport system for the amino acid proline in unstimulated lymphocytes decays with a half-life of about 4 h when protein synthesis is inhibited by cycloheximide, but the system in mitogen-activated lymphocytes is more stable. However, the early increase in activity of this transport system after mitogen addition is not due to a direct effect on its stability, but is a secondary effect requiring protein synthesis.
摘要
在未受刺激的淋巴细胞中，脯氨酸的钠依赖性转运系统在蛋白质合成被放线菌酮抑制时，以约4小时的半衰期衰减，但有丝分裂原激活的淋巴细胞中的该系统更稳定。然而，添加有丝分裂原后该转运系统活性的早期增加并非由于对其稳定性的直接影响，而是需要蛋白质合成的次级效应。
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本文引用的文献
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Regulation of amino acid transport in chick embryo heart cells. II. Adaptive control sites for the "A mediation".鸡胚心脏细胞中氨基酸转运的调节。II. “A介导”的适应性控制位点。
Biochim Biophys Acta. 1973 Jan 26;291(2):545-56. doi: 10.1016/0005-2736(73)90506-3.
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Increased transport of 2-aminoisobutyric acid in rat lymphocytes stimulated with concanavalin A.伴刀豆球蛋白A刺激的大鼠淋巴细胞中2-氨基异丁酸转运增加。
Exp Cell Res. 1973 Jan;76(1):63-72. doi: 10.1016/0014-4827(73)90419-9.
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Effect of actinomycin on protein synthesis by lymphocytes.放线菌素对淋巴细胞蛋白质合成的影响。
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