Muschel L H, Gustafson L
J Bacteriol. 1968 Jun;95(6):2010-3. doi: 10.1128/jb.95.6.2010-2013.1968.
Antimicrobial substances, including antibiotics such as polymyxin and novobiocin, detergents, and complement, all of which are known or presumed to have an effect upon membrane permeability, showed greater potency against ethylenediaminetetraacetic acid (EDTA)-treated Salmonella typhi than against untreated cells of that organism. The differential effect was particularly marked with the complement system when serum antibody was limiting. EDTA-treated cells were also more susceptible to penicillin and bacitracin. On the other hand, such treatment did not affect the potency against S. typhi of mitomycin C, the aminoglycosides, chloramphenicol, and chlortetracycline, nor did it affect the permeability of S. typhi to these compounds.
抗菌物质，包括多粘菌素和新生霉素等抗生素、去污剂及补体，所有这些物质已知或被推测会对膜通透性产生影响，它们对经乙二胺四乙酸（EDTA）处理的伤寒沙门氏菌的效力比对该生物体未处理细胞的效力更强。当血清抗体有限时，补体系统的这种差异效应尤为明显。经EDTA处理的细胞对青霉素和杆菌肽也更敏感。另一方面，这种处理并不影响丝裂霉素C、氨基糖苷类、氯霉素和金霉素对伤寒沙门氏菌的效力，也不影响伤寒沙门氏菌对这些化合物的通透性。
